2016
A framework for designing dynamic lp-ntPET studies to maximize the sensitivity to transient neurotransmitter responses to drugs: Application to dopamine and smoking
Wang S, Kim S, Cosgrove KP, Morris ED. A framework for designing dynamic lp-ntPET studies to maximize the sensitivity to transient neurotransmitter responses to drugs: Application to dopamine and smoking. NeuroImage 2016, 146: 701-714. PMID: 27743899, PMCID: PMC5321849, DOI: 10.1016/j.neuroimage.2016.10.019.Peer-Reviewed Original ResearchConceptsNeurotransmitter responsesCigarette smokingDrug stimuliDA releaseDA activationBolus injectionMild shorteningPET scansOptimal timingSmokingDopamine responsePET dataLp-ntPETDose limitTime courseSex differencesScansLoss of sensitivityBehavioral tasksDrugsLinear parametric neurotransmitter PETLower dose limitSuch responsesResponseStimuli
2014
Sex Differences in the Brain's Dopamine Signature of Cigarette Smoking
Cosgrove KP, Wang S, Kim SJ, McGovern E, Nabulsi N, Gao H, Labaree D, Tagare HD, Sullivan JM, Morris ED. Sex Differences in the Brain's Dopamine Signature of Cigarette Smoking. Journal Of Neuroscience 2014, 34: 16851-16855. PMID: 25505336, PMCID: PMC4261105, DOI: 10.1523/jneurosci.3661-14.2014.Peer-Reviewed Original ResearchConceptsCigarette smokingVentral striatumCigarette smoking differsEffect of smokingEarly PET studiesMesolimbic dopamine systemRight ventral striatumSex differencesDopaminergic eventsMale smokersNicotine patchCessation treatmentFemale smokersDorsal putamenDopaminergic responseBrain scanningSmoking differsDrug effectsDopamine systemSmokingNeurotransmitter releasePublic health dangerPET studiesCue reactivityWomen