2001
Structure and function of GABAC receptors: a comparison of native versus recombinant receptors
Zhang D, Pan Z, Awobuluyi M, Lipton S. Structure and function of GABAC receptors: a comparison of native versus recombinant receptors. Trends In Pharmacological Sciences 2001, 22: 121-132. PMID: 11239575, DOI: 10.1016/s0165-6147(00)01625-4.Peer-Reviewed Original ResearchConceptsRecombinant receptorsGABA receptorsIonotropic GABA receptorsRetinal signal processingInhibitory receptorsGABAC receptorsPharmacological profileBrain regionsSpecific drugsReceptorsNative receptorMajor molecular componentsUnique functional rolesFunctional roleMolecular determinantsSlow activationCompelling evidenceSubunit compositionMolecular basisRetina
1996
Nitric oxide-related species inhibit evoked neurotransmission but enhance spontaneous miniature synaptic currents in central neuronal cultures
Pan Z, Segal M, Lipton S. Nitric oxide-related species inhibit evoked neurotransmission but enhance spontaneous miniature synaptic currents in central neuronal cultures. Proceedings Of The National Academy Of Sciences Of The United States Of America 1996, 93: 15423-15428. PMID: 8986827, PMCID: PMC26420, DOI: 10.1073/pnas.93.26.15423.Peer-Reviewed Original ResearchConceptsMiniature excitatory postsynaptic currentsSpontaneous miniature excitatory postsynaptic currentsSpontaneous miniature synaptic currentsExcitatory postsynaptic currentsMiniature synaptic currentsPure NO donorPostsynaptic currentsSynaptic activitySynaptic currentsNeuronal culturesNO donorNitric oxideNO donor moleculesNeurotransmissionNitric oxide-related speciesParadoxical observationEPSCsDonors
1986
Blockade of electrical activity promotes the death of mammalian retinal ganglion cells in culture.
Lipton S. Blockade of electrical activity promotes the death of mammalian retinal ganglion cells in culture. Proceedings Of The National Academy Of Sciences Of The United States Of America 1986, 83: 9774-9778. PMID: 3025849, PMCID: PMC387224, DOI: 10.1073/pnas.83.24.9774.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsCalciumCell SurvivalCells, CulturedCulture MediaMagnesiumRatsRetinaRetinal Ganglion CellsSynaptic TransmissionTetrodotoxinConceptsRetinal ganglion cellsGanglion cellsNatural cell deathElectrical activityDeath of RGCsMammalian retinal ganglion cellsCell deathLevel of activityPostnatal day 2Spontaneous electrical activityElectrical blockadeIntraocular injectionMicroM tetrodotoxinPostnatal weekNeuronal activitySpontaneous activityTrophic factorsPostnatal ratsMammalian retinaDevelopment neuronsDay 2TetrodotoxinBlockadeIndividual neuronsAltered activity