2024
Using in vivo intact structure for system-wide quantitative analysis of changes in proteins
Son A, Kim H, Diedrich J, Bamberger C, McClatchy D, Lipton S, Yates J. Using in vivo intact structure for system-wide quantitative analysis of changes in proteins. Nature Communications 2024, 15: 9310. PMID: 39468068, PMCID: PMC11519357, DOI: 10.1038/s41467-024-53582-x.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseProtein footprinting methodGlobal expression profilingIn vivo conformationStructural alterations of proteinsCo-expressed proteinsMass spectrometry-based methodsAlterations of proteinsProteostasis dysfunctionSpectrometry-based methodsProtein misfoldingConformation of proteinsStructural changesLysine residuesDynamic structural changesBiological functionsProteomics experimentsDimethyl labelingExpression profilesProtein conformationConformational changesProteinIntact proteinDesign of therapeutic interventionsMeasuring dynamic structural changes
2023
Restorative effect of NitroSynapsin on synaptic plasticity in an animal model of depression
Tse W, Pochwat B, Szewczyk B, Misztak P, Bobula B, Tokarski K, Worch R, Czarnota-Bojarska M, Lipton S, Zaręba-Kozioł M, Bijata M, Wlodarczyk J. Restorative effect of NitroSynapsin on synaptic plasticity in an animal model of depression. Neuropharmacology 2023, 241: 109729. PMID: 37797736, DOI: 10.1016/j.neuropharm.2023.109729.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexLong-term potentiationChronic restraint stress mouse modelSynaptic plasticityN-methyl-D-aspartate receptor antagonistRestraint stress mouse modelMale C57BL/6J miceAntidepressant-like activityTail suspension testStress mouse modelFunctional synaptic plasticityMajor depressive disorderAntidepressant potentialPharmacological treatmentPsychotomimetic effectsReceptor antagonistC57BL/6J miceDepressive behaviorSucrose preferenceDepressive disorderNitroSynapsinMouse modelSuspension testBehavioral disturbancesCerebrocortical neurons
2022
Mechanistic insight into female predominance in Alzheimer’s disease based on aberrant protein S-nitrosylation of C3
Yang H, Oh C, Amal H, Wishnok J, Lewis S, Schahrer E, Trudler D, Nakamura T, Tannenbaum S, Lipton S. Mechanistic insight into female predominance in Alzheimer’s disease based on aberrant protein S-nitrosylation of C3. Science Advances 2022, 8: eade0764. PMID: 36516243, PMCID: PMC9750152, DOI: 10.1126/sciadv.ade0764.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseAD brainPostmortem Alzheimer's diseaseComplement component 3Sex-dependent mannerConsequent cognitive declineSynaptic phagocytosisΒ-estradiol levelsFemale predominanceAberrant protein S-nitrosylationSynaptic damageAD pathogenesisSNO proteinsCognitive declineProtein SDiseaseRobust alterationsBrainComponent 3Protein S-nitrosylationHuman brainS-nitrosylationS-nitrosoproteomePatientsPathogenesisS-Nitrosylation of p62 Inhibits Autophagic Flux to Promote α-Synuclein Secretion and Spread in Parkinson's Disease and Lewy Body Dementia
Oh C, Dolatabadi N, Cieplak P, Diaz-Meco M, Moscat J, Nolan J, Nakamura T, Lipton S. S-Nitrosylation of p62 Inhibits Autophagic Flux to Promote α-Synuclein Secretion and Spread in Parkinson's Disease and Lewy Body Dementia. Journal Of Neuroscience 2022, 42: 3011-3024. PMID: 35169022, PMCID: PMC8985870, DOI: 10.1523/jneurosci.1508-21.2022.Peer-Reviewed Original ResearchConceptsLewy body dementiaParkinson's diseaseAutophagic fluxInhibits autophagic fluxΑ-synucleinPluripotent stem cell-derived neuronsStem cell-derived neuronsΑ-synuclein secretionS-nitrosylationCell-derived neuronsHuman postmortem brainProtein S-nitrosylationΑ-synuclein aggregationPostmortem brainsConsequent secretionPathologic pathwaysNervous systemAdaptor protein p62Autophagic inhibitionDysfunctional autophagyNeurodegenerative disordersDiseaseIndividual neuronsDementiaSecretion
2021
TCA cycle metabolic compromise due to an aberrant S-nitrosoproteome in HIV-associated neurocognitive disorder with methamphetamine use
Doulias P, Nakamura T, Scott H, McKercher S, Sultan A, Deal A, Albertolle M, Ischiropoulos H, Lipton S. TCA cycle metabolic compromise due to an aberrant S-nitrosoproteome in HIV-associated neurocognitive disorder with methamphetamine use. Journal Of NeuroVirology 2021, 27: 367-378. PMID: 33876414, PMCID: PMC8477648, DOI: 10.1007/s13365-021-00970-4.Peer-Reviewed Original ResearchConceptsNeurocognitive disordersMeth usePathogenesis of HIVHuman postmortem brainAberrant protein S-nitrosylationCNS pathologyControl brainsSynaptic damageS-nitrosylationHIV-1Metabolic compromisePostmortem brainsMethamphetamine useNitric oxideDrug abuseRedox stressNitrosative stressBrainHIVProtein S-nitrosylationDisordersS-nitrosoproteomeSystematic inhibitionTCA cycle enzymesPathogenesisα-Synuclein Oligomers Induce Glutamate Release from Astrocytes and Excessive Extrasynaptic NMDAR Activity in Neurons, Thus Contributing to Synapse Loss
Trudler D, Sanz-Blasco S, Eisele Y, Ghatak S, Bodhinathan K, Akhtar M, Lynch W, Piña-Crespo J, Talantova M, Kelly J, Lipton S. α-Synuclein Oligomers Induce Glutamate Release from Astrocytes and Excessive Extrasynaptic NMDAR Activity in Neurons, Thus Contributing to Synapse Loss. Journal Of Neuroscience 2021, 41: 2264-2273. PMID: 33483428, PMCID: PMC8018774, DOI: 10.1523/jneurosci.1871-20.2020.Peer-Reviewed Original ResearchConceptsLewy body dementiaExtrasynaptic NMDA receptorsSynaptic damageParkinson's diseaseNeuronal lossLewy bodiesNMDAR activityDisease progressionΑSyn oligomersPotential disease-modifying interventionsNeurodegenerative diseasesΑ-synucleinExtrasynaptic NMDAR activitySynaptic NMDAR activityDisease-modifying interventionsPatch-clamp recordingsMajor neuropathological characteristicsSynaptic lossAstrocytic glutamateGlutamate releaseSynapse lossSpine lossExtrasynaptic NMDARsFemale miceHippocampal slices
2016
The Veterans Aging Cohort Study (VACS) Index and Neurocognitive Change: A Longitudinal Study
Marquine M, Montoya J, Umlauf A, Fazeli P, Gouaux B, Heaton R, Ellis R, Letendre S, Grant I, Moore D, Group F, Heaton R, Grant I, Atkinson J, Ellis R, Letendre S, Marcotte T, Marquie-Beck J, Sherman M, Ellis R, Letendre S, McCutchan J, Best B, Schrier R, Rosario D, Heaton R, Atkinson J, Woods S, Marcotte T, Cherner M, Moore D, Dawson M, Fennema-Notestine C, Buchsbaum M, Hesselink J, Archibald S, Brown G, Buxton R, Dale A, Liu T, Masliah E, Achim C, Smith D, Richman D, McCutchan J, Cherner M, Achim C, Lipton S, Atkinson J, Marquie-Beck J, Gamst A, Cushman C, Abramson I, Vaida F, Deutsch R, Umlauf A. The Veterans Aging Cohort Study (VACS) Index and Neurocognitive Change: A Longitudinal Study. Clinical Infectious Diseases 2016, 63: 694-702. PMID: 27199461, PMCID: PMC4981756, DOI: 10.1093/cid/ciw328.Peer-Reviewed Original ResearchConceptsVACS Index scoreVeterans Aging Cohort Study (VACS) IndexHigher VACS Index scoresVACS IndexNeurocognitive impairmentIndex scoreT-scoreNeurocognitive changesHIV Neurobehavioral Research ProgramStudy indicesIncident neurocognitive impairmentHuman immunodeficiency virusGlobal deficit scoreSubgroup of personsUpper quartile groupGlobal T-scoresLongitudinal neurocognitive changesCohort studyDeficit scoresImmunodeficiency virusLowest quartileNeurocognitive statusNeurocognitive functionDisease severityComprehensive neurocognitive batteryPill Burden Influences the Association Between Time-Based Prospective Memory and Antiretroviral Therapy Adherence in Younger But Not Older HIV-Infected Adults
Sheppard D, Weber E, Casaletto K, Avci G, Woods S, Grant I, Atkinson J, Ellis R, McCutchan J, Marcotte T, Marquie-Beck J, Sherman M, Ellis R, McCutchan J, Letendre S, Capparelli E, Schrier R, Rosario D, Heaton R, Cherner M, Iudicello J, Moore D, Morgan E, Dawson M, Jernigan T, Fennema-Notestine C, Archibald S, Hesselink J, Annese J, Taylor M, Masliah E, Achim C, Everall I, Richman D, Smith D, McCutchan J, Achim C, Lipton S, Atkinson J, Gamst A, Cushman C, Abramson I, Vaida F, Deutsch R, Umlauf A. Pill Burden Influences the Association Between Time-Based Prospective Memory and Antiretroviral Therapy Adherence in Younger But Not Older HIV-Infected Adults. Journal Of The Association Of Nurses In AIDS Care 2016, 27: 595-607. PMID: 27160771, PMCID: PMC4976032, DOI: 10.1016/j.jana.2016.03.006.Peer-Reviewed Original ResearchConceptsLow pill burdenPill burdenYoung HIVMedication Event Monitoring SystemHigh pill burdenAntiretroviral therapy adherenceEvent Monitoring SystemARV adherenceOlder HIVAntiretroviral adherenceTherapy adherenceHIVOlder groupAdherenceSuboptimal useHigher likelihoodBurdenTime-based prospective memoryMeasures of PMAdultsAssociationNonadherenceHealth-Related Everyday Functioning in the Internet Age: HIV-Associated Neurocognitive Disorders Disrupt Online Pharmacy and Health Chart Navigation Skills
Woods S, Iudicello J, Morgan E, Cameron M, Doyle K, Smith T, Cushman C, Group T, Grant I, Atkinson J, Ellis R, McCutchan J, Marcotte T, Marquie-Beck J, Sherman M, Ellis R, McCutchan J, Letendre S, Capparelli E, Schrier R, Rosario D, Heaton R, Cherner M, Iudicello J, Moore D, Morgan E, Dawson M, Jernigan T, Fennema-Notestine C, Archibald S, Hesselink J, Annese J, Taylor M, Masliah E, Achim C, Everall I, Richman D, Smith D, McCutchan J, Achim C, Lipton S, Atkinson J, Gamst A, Cushman C, Abramson I, Vaida F, Deutsch R, Umlauf A, DeLuca J, Goverover Y, Franklin D, Corkran S. Health-Related Everyday Functioning in the Internet Age: HIV-Associated Neurocognitive Disorders Disrupt Online Pharmacy and Health Chart Navigation Skills. Archives Of Clinical Neuropsychology 2016, 31: 176-185. PMID: 26743327, PMCID: PMC4758381, DOI: 10.1093/arclin/acv090.Peer-Reviewed Original ResearchConceptsHealth-related behaviorsNeurocognitive disordersHigh plasma viral loadHIV-Associated Neurocognitive DisordersPlasma viral loadEffects of HIVLow health literacyImportant health-related behaviorsHIV infectionViral loadHealth literacyYears of educationOnline pharmaciesStudy participantsPharmacyDisordersFrequent Internet useParticipantsHealthcare managementSeronegativesHIVNavigation skillsInfectionIndividuals
2014
Self-Predictions of Prospective Memory in HIV-Associated Neurocognitive Disorders: Evidence of a Metamemory Deficit
Casaletto K, Doyle K, Weber E, Woods S, Heaton R, Grant I, Atkinson J, Ellis R, Letendre S, Marcotte T, Marquie-Beck J, Sherman M, Ellis R, Letendre S, McCutchan J, Best B, Schrier R, Rosario D, Heaton R, Atkinson J, Woods S, Psy D, Marcotte T, Cherner M, Moore D, Dawson M, Fennema-Notestine C, Buchsbaum M, Hesselink J, Archibald S, Brown G, Buxton R, Dale A, Liu T, Masliah E, Achim C, Smith D, Richman D, McCutchan J, Cherner M, Achim C, Lipton S, Atkinson J, Marquie-Beck J, Gamst A, Cushman C, Abramson I, Vaida F, Deutsch R, Umlauf A. Self-Predictions of Prospective Memory in HIV-Associated Neurocognitive Disorders: Evidence of a Metamemory Deficit. Archives Of Clinical Neuropsychology 2014, 29: 818-827. PMID: 25404005, PMCID: PMC4296161, DOI: 10.1093/arclin/acu061.Peer-Reviewed Original ResearchConceptsPM performancePM abilitiesProspective memoryPM functioningHand individualsCompensatory strategy useSelf-reported predictionGroup-level differencesEveryday lifeNeurocognitive disordersMetamemory deficitHIV-Associated Neurocognitive DisordersStrategy useExecutive dysfunctionSelf-PredictionPossible deficitsDaily functioningModerate deficitsHand groupPM symptomsOverconfidenceAntiretroviral nonadherenceFunctioningDeficitsMemoryCognitive deficits associated with combined HIV gp120 expression and chronic methamphetamine exposure in mice
Kesby J, Markou A, Semenova S, Grant I, Ellis R, Letendre S, Achim C, Woods S, Carr A, Letendre S, Ellis R, Schrier R, Heaton R, Atkinson J, Cherner M, Marcotte T, Morgan E, Brown G, Jernigan T, Dale A, Liu T, Scadeng M, Fennema-Notestine C, Archibald S, Achim C, Masliah E, Lipton S, Soontornniyomkij V, Gamst A, Cushman C, Abramson I, Vaida F, Deutsch R, Umlauf A, Atkinson J, Marquie-Beck J, Minassian A, Perry W, Geyer M, Henry B, Young J, Grethe A, Paulus M, Ellis R, Morris S, Smith D, Grant I, Semenova S, Markou A, Kesby J, Kaul M. Cognitive deficits associated with combined HIV gp120 expression and chronic methamphetamine exposure in mice. European Neuropsychopharmacology 2014, 25: 141-150. PMID: 25476577, PMCID: PMC4289653, DOI: 10.1016/j.euroneuro.2014.07.014.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, OcularAnalysis of VarianceAnimalsBody WeightCentral Nervous System StimulantsCognition DisordersDisease Models, AnimalGene Expression RegulationGlial Fibrillary Acidic ProteinHIV Envelope Protein gp120MaleMaze LearningMethamphetamineMiceMice, Inbred C57BLMice, TransgenicReaction TimeRecognition, PsychologyConceptsGp120-tg miceCognitive domainsBarnes mazeMethamphetamine exposureCognitive deficitsSpatial learningAssociative recognition memoryDiscrete cognitive domainsMethamphetamine abuseHuman immunodeficiency virusRecognition memoryExecutive functionBarnes maze testCognitive performanceChronic methamphetamine exposureCognitive functionGp120 expressionAcquisition trialsGreater deficitsHIV infectionPlace testStrategy scoresNeurocognitive outcomesMethamphetamine usersSpatial strategiesShallow Encoding and Forgetting Are Associated with Dependence in Instrumental Activities of Daily Living Among Older Adults Living with HIV Infection
Fazeli P, Doyle K, Scott J, Iudicello J, Casaletto K, Weber E, Moore D, Morgan E, Grant I, Woods S, Hampton Atkinson J, Ellis R, Allen McCutchan J, Marcotte T, Marquie-Beck J, Sherman M, Ellis R, Allen McCutchan J, Letendre S, Capparelli E, Schrier R, Rosario D, LeBlanc S, Heaton R, Woods S, Cherner M, Moore D, Morgan E, Dawson M, Jernigan T, Fennema-Notestine C, Archibald S, Hesselink J, Annese J, Taylor M, Masliah E, Achim C, Everall I, Richman D, Smith D, Allen McCutchan J, Achim C, Lipton S, Hampton Atkinson J, Gamst A, Cushman C, Abramson I, Vaida F, Deutsch R, Umlauf A. Shallow Encoding and Forgetting Are Associated with Dependence in Instrumental Activities of Daily Living Among Older Adults Living with HIV Infection. Archives Of Clinical Neuropsychology 2014, 29: 278-288. PMID: 24695591, PMCID: PMC4000232, DOI: 10.1093/arclin/acu009.Peer-Reviewed Original ResearchConceptsCalifornia Verbal Learning Test-Second EditionMemory deficitsIADL dependenceReal-world functioningLogical Memory subtestInstrumental activitiesMemory subtestsShallow encodingRecency effectMemory predictorsDaily livingOlder adultsWorse performanceForgettingOlder groupEncodingOlder HIVADL questionnaireHIV infectionRisk factorsDeficitsHIVAdultsSubtestsYounger cohorts
2011
Are Time- and Event-based Prospective Memory Comparably Affected in HIV Infection?†
Zogg J, Woods S, Weber E, Doyle K, Grant I, Group T, Atkinson J, Ellis R, McCutchan J, Marcotte T, Hale B, Ellis R, McCutchan J, Letendre S, Capparelli E, Schrier R, Heaton R, Cherner M, Moore D, Jernigan T, Fennema-Notestine C, Archibald S, Hesselink J, Annese J, Taylor M, Masliah E, Everall I, Langford T, Richman D, Smith D, McCutchan J, Everall I, Lipton S, McCutchan J, Atkinson J, Ellis R, Letendre S, Atkinson J, von Jaeger R, Gamst A, Cushman C, Masys D, Abramson I, Ake C, Vaida F. Are Time- and Event-based Prospective Memory Comparably Affected in HIV Infection?†. Archives Of Clinical Neuropsychology 2011, 26: 250-259. PMID: 21459901, PMCID: PMC3081684, DOI: 10.1093/arclin/acr020.Peer-Reviewed Original ResearchConceptsEvent-based ProMIntentions Screening TestTime-based tasksEvent-based tasksMulti-process theoryTrend-level effectsProspective memoryCue typesCognitive architectureAttention/Executive functionVerbal fluencyPrefrontal systemsSubset of participantsStrategic monitoringParallel subscalesGreater deficitsRetrieval processStrategic processMemoryMain effectNeurocognitive disordersTaskDeficitsPrior studies
2005
HIV leucoencephalopathy and TNFα expression in neurones
Rostasy K, Monti L, Lipton S, Hedreen J, Gonzalez R, Navia B. HIV leucoencephalopathy and TNFα expression in neurones. Journal Of Neurology Neurosurgery & Psychiatry 2005, 76: 960. PMID: 15965202, PMCID: PMC1739718, DOI: 10.1136/jnnp.2004.036889.Peer-Reviewed Original ResearchMeSH KeywordsAdultAIDS Dementia ComplexAnti-Retroviral AgentsBasal GangliaBiopsyBrainDiffusion Magnetic Resonance ImagingDisease ProgressionFollow-Up StudiesFrontal LobeHIV Envelope Protein gp41HumansMacrophagesMaleMicrogliaMiddle AgedNeurologic ExaminationNeuronsNeuropsychological TestsSaquinavirStavudineTreatment OutcomeTumor Necrosis Factor-alphaZidovudineConceptsAIDS dementia complexPathogenesis of ADCImaging studiesMicroglia/macrophage activationProgressive formDeep white matter changesMicroglia/macrophagesExpression of TNFalphaWhite matter changesNecrosis factor alphaMeans of immunohistochemistryViral protein expressionNeuroradiological featuresAntiretroviral treatmentHIV infectionThird patientBrain biopsyProgressive dementiaDementia complexTreatment regimensBasal gangliaClinical historyFactor alphaTNFα expressionFrontal cortex
2000
Role of p38 Mitogen-Activated Protein Kinase in Axotomy-Induced Apoptosis of Rat Retinal Ganglion Cells
Kikuchi M, Tenneti L, Lipton S. Role of p38 Mitogen-Activated Protein Kinase in Axotomy-Induced Apoptosis of Rat Retinal Ganglion Cells. Journal Of Neuroscience 2000, 20: 5037-5044. PMID: 10864961, PMCID: PMC6772303, DOI: 10.1523/jneurosci.20-13-05037.2000.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisAxonal TransportAxotomyCell NucleusCell SurvivalDizocilpine MaleateEnzyme InhibitorsFluorescent DyesImidazolesKineticsMaleMitogen-Activated Protein KinasesNeuroprotective AgentsOptic NerveP38 Mitogen-Activated Protein KinasesPhosphorylationPyridinesRatsRats, Long-EvansRetinal Ganglion CellsSignal TransductionStilbamidinesTime FactorsConceptsRetinal ganglion cellsProtein kinaseP38 Mitogen-Activated Protein KinaseMitogen-Activated Protein KinaseMAP kinase activationIntracellular signal transductionRole of p38P38 MAP kinase activationApoptotic cell deathDose-dependent mannerP38 MAP kinase inhibitorMAP kinase inhibitorRGC apoptosisOptic nerveGanglion cellsSignal transductionNMDA receptorsAxotomy-induced apoptosisApoptotic signalingKinase activationP38 inhibitorRat retinal ganglion cellsCell deathCell typesOptic nerve trauma
1999
The contribution of various NOS gene products to HIV-1 coat protein (gp120)-mediated retinal ganglion cell injury.
Dreyer E, Zurakowski D, Gorla M, Vorwerk C, Lipton S. The contribution of various NOS gene products to HIV-1 coat protein (gp120)-mediated retinal ganglion cell injury. Investigative Ophthalmology & Visual Science 1999, 40: 983-9. PMID: 10102296.Peer-Reviewed Original ResearchConceptsNitric oxide synthaseHIV-1 coat proteinRetinal ganglion cell injuryIsoforms of NOSNitric oxideNeuronal nitric oxide synthaseGanglion cell injuryRetinal ganglion cellsPresence of nNOSNOS-deficient miceWild-type miceNeuronal lossExcitotoxic pathwayIntravitreal injectionGanglion cellsGp120 toxicityNeuronal pathologyNOS inhibitorOxide synthaseHIV-1Cell injuryControl animalsNervous systemGp120Pathologic states
1998
A phase I/II trial of nimodipine for HIV-related neurologic complications
Navia B, Dafni U, Simpson D, Tucker T, Singer E, McArthur J, Yiannoutsos C, Zaborski L, Lipton S. A phase I/II trial of nimodipine for HIV-related neurologic complications. Neurology 1998, 51: 221-228. PMID: 9674806, DOI: 10.1212/wnl.51.1.221.Peer-Reviewed Original ResearchConceptsAIDS dementia complexVoltage-dependent calcium channel antagonistsPhase I/II trialSevere AIDS-dementia complexHigh-dose armPhase II studyFurther clinical trialsCalcium channel antagonistsNPZ-8Adjuvant treatmentAntiretroviral therapyII trialNeurologic complicationsNeuropsychological z scoresNeuronal injuryHIV infectionPeripheral neuropathyTreat analysisCSF levelsDementia complexImmune activationClinical trialsNeurologic disordersChannel antagonistsPossible efficacyNeuroprotective concentrations of the N-methyl-D-aspartate open-channel blocker memantine are effective without cytoplasmic vacuolation following post-ischemic administration and do not block maze learning or long-term potentiation
Chen H, Wang Y, Rayudu P, Edgecomb P, Neill J, Segal M, Lipton S, Jensen F. Neuroprotective concentrations of the N-methyl-D-aspartate open-channel blocker memantine are effective without cytoplasmic vacuolation following post-ischemic administration and do not block maze learning or long-term potentiation. Neuroscience 1998, 86: 1121-1132. PMID: 9697119, DOI: 10.1016/s0306-4522(98)00163-8.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBody TemperatureBrain IschemiaCytoplasmExcitatory Amino Acid AntagonistsExcitatory Postsynaptic PotentialsIn Vitro TechniquesLong-Term PotentiationMaleMaze LearningMemantineMicroscopy, ElectronNeuronsNeuroprotective AgentsRatsRats, Sprague-DawleyReceptors, N-Methyl-D-AspartateVacuolesConceptsN-methyl-D-aspartate antagonistsLong-term potentiationAspartate antagonistDizocilpine maleateSide effectsUncompetitive N-methyl-D-aspartate antagonistsN-methyl-D-aspartate blockersMorris water maze performancePost-ischemic administrationHypoxia/ischemiaExcitatory postsynaptic currentsN-methyl-D-aspartate (NMDA) channelsAdverse side effectsWater maze performanceHuman CNS disordersExcitotoxic disordersNeuroprotective concentrationsClinical tolerabilityNeuroprotective dosesClinical efficacyInfarct sizePostsynaptic currentsHippocampal slicesCNS disordersAdult ratsNitrate therapy may retard glaucomatous optic neuropathy, perhaps through modulation of glutamate receptors
Zurakowski D, Vorwerk C, Gorla M, Kanellopoulos A, Chaturvedi N, Grosskreutz C, Lipton S, Dreyer E. Nitrate therapy may retard glaucomatous optic neuropathy, perhaps through modulation of glutamate receptors. Vision Research 1998, 38: 1489-1494. PMID: 9667013, DOI: 10.1016/s0042-6989(98)00003-0.Peer-Reviewed Original ResearchConceptsEffects of nitroglycerinGlaucomatous optic neuropathyRetinal ganglion cellsAnginal symptomsNitroglycerin preparationsNitrate therapyGlaucomatous damageOptic neuropathyIntraocular pressureGanglion cellsGlutamate receptorsGlaucomatous blindnessNitroglycerinCell deathNeuropathyTherapySymptomsReceptorsIncreased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3A
Das S, Sasaki Y, Rothe T, Premkumar L, Takasu M, Crandall J, Dikkes P, Conner D, Rayudu P, Cheung W, Chen H, Lipton S, Nakanishi N. Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3A. Nature 1998, 393: 377-381. PMID: 9620802, DOI: 10.1038/30748.Peer-Reviewed Original ResearchConceptsNMDA receptorsReceptor subunit NR1Synaptic refinementSpine densityNMDA receptor subunit NR3ANMDA responsesNMDA subclassSmall unitary conductanceNMDAR activitySubunit NR1NMDAR subunitsCerebrocortical neuronsDendritic spinesSynaptic plasticityNR1 subunitMice resultsSingle-channel recordingsGenetic knockoutSynaptic elementsHeteromultimeric channelsNR1NR3AXenopus oocytesUnitary conductanceNMDA