2009
Molecular stages of rapid and uniform neuralization of human embryonic stem cells
Bajpai R, Coppola G, Kaul M, Talantova M, Cimadamore F, Nilbratt M, Geschwind D, Lipton S, Terskikh A. Molecular stages of rapid and uniform neuralization of human embryonic stem cells. Cell Death & Differentiation 2009, 16: 807-825. PMID: 19282867, PMCID: PMC3432273, DOI: 10.1038/cdd.2009.18.Peer-Reviewed Original ResearchConceptsHuman embryonic stem cellsEmbryonic stem cellsNeural precursor cellsDynamic gene expression analysisStem cellsGene expression changesPrecursor cellsGene expression analysisEarly human developmentCoregulated genesPrimitive ectodermExpression analysisExpression changesMouse brainPotent oncogeneMolecular signalingUniform differentiationHuman biologyEfficient differentiationFuture cell-based therapiesFunctional neuronsNeuralizationPosterior markersNeonatal mouse brainNeural proliferation
2000
Expression of GABAC receptor ρ1 and ρ2 subunits during development of the mouse retina
Greka A, Lipton S, Zhang D. Expression of GABAC receptor ρ1 and ρ2 subunits during development of the mouse retina. European Journal Of Neuroscience 2000, 12: 3575-3582. PMID: 11029627, DOI: 10.1046/j.1460-9568.2000.00247.x.Peer-Reviewed Original ResearchConceptsRetinal developmentGamma-aminobutyric acid type C receptorMouse retinaRho subunitsReceptor-mediated currentsPostnatal day 6Type C receptorsBipolar cell differentiationMouse retinal developmentΡ2 subunitsBipolar cellsC receptorRho2 subunitsRho1 subunitDay 6ReceptorsEye openingSubunit transcriptionSubunit messageAdulthoodRetinaFuture studiesCompetitive PCRCell differentiationP9
1999
Neuroprotection by the NMDA receptor-associated open-channel blocker memantine in a photothrombotic model of cerebral focal ischemia in neonatal rat
Stieg P, Sathi S, Warach S, Le D, Lipton S. Neuroprotection by the NMDA receptor-associated open-channel blocker memantine in a photothrombotic model of cerebral focal ischemia in neonatal rat. European Journal Of Pharmacology 1999, 375: 115-120. PMID: 10443569, DOI: 10.1016/s0014-2999(99)00214-9.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingSide effectsInfarct sizeNeonatal ratsChannel blockersNMDA receptorsFocal cerebral ischemia modelNeurobehavioral side effectsIschemic brain injuryEffects of memantineExcitatory amino acidsInduction of strokeRodent stroke modelsAdult animal modelsCerebral ischemia modelSubstantial side effectsCerebral focal ischemiaNumerous side effectsNeuronal cell culturesNeonatal neuronsPhotochemical thrombosisPhotothrombotic modelNeuronal injuryCerebral ischemiaFocal ischemia
1990
Neural nicotinic acetylcholine responses in sensory neurons from postnatal rat
Sucher N, Cheng T, Lipton S. Neural nicotinic acetylcholine responses in sensory neurons from postnatal rat. Brain Research 1990, 533: 248-254. PMID: 2289141, DOI: 10.1016/0006-8993(90)91346-i.Peer-Reviewed Original ResearchConceptsDRG cellsPostnatal ratsInward currentsFunctional nicotinic acetylcholine receptorsDorsal root ganglion cellsNicotinic acetylcholine responsesAgonist-induced currentsNicotinic acetylcholine receptorsPatch-clamp techniqueWhole-cell configurationAcetylcholine responseNicotinic responsesGanglion cellsNeuronal bungarotoxinNeuronal typesSensory neuronsNicotinic acetylcholineAcetylcholine receptorsNewborn animalsAcetylcholineIrreversible blockPresence of toxinsRatsCellsDMPPRedox modulation of NMDA receptor-mediated Ca2+ flux in mammalian central neurons
Sucher N, Wong L, Lipton S. Redox modulation of NMDA receptor-mediated Ca2+ flux in mammalian central neurons. Neuroreport 1990, 1: 29-32. PMID: 2151794, DOI: 10.1097/00001756-199009000-00009.Peer-Reviewed Original Research
1989
Characterization of nicotinic receptors in chick retina using a snake venom neurotoxin that blocks neuronal nicotinic receptor function
Loring R, Aizenman E, Lipton, Zigmond R. Characterization of nicotinic receptors in chick retina using a snake venom neurotoxin that blocks neuronal nicotinic receptor function. Journal Of Neuroscience 1989, 9: 2423-2431. PMID: 2746336, PMCID: PMC6569765, DOI: 10.1523/jneurosci.09-07-02423.1989.Peer-Reviewed Original ResearchConceptsNicotinic receptor functionNicotinic receptorsChick retinaNicotinic agonistsReceptor functionNeuronal nicotinic receptor functionIntact chick retinaFunctional nicotinic receptorsInner plexiform layerAutonomic gangliaGanglion cellsPlexiform layerCholine acetyltransferaseNeuronal bungarotoxinNeuromuscular antagonistsNicotinic functionNeuronal preparationsRetinaAgonistsReceptorsAntagonistSnake venom neurotoxinsVenom neurotoxinsLow affinityHigh affinity