2000
Nitric oxide (NO·) stabilizes whereas nitrosonium (NO+) enhances filopodial outgrowth by rat retinal ganglion cells in vitro
Cheung S, Bhan I, Lipton S. Nitric oxide (NO·) stabilizes whereas nitrosonium (NO+) enhances filopodial outgrowth by rat retinal ganglion cells in vitro. Brain Research 2000, 868: 1-13. PMID: 10841882, DOI: 10.1016/s0006-8993(00)02161-2.Peer-Reviewed Original ResearchConceptsRat retinal ganglion cellsRetinal ganglion cellsGanglion cellsNitric oxideInhibition of NOSNO synthase substrateGrowth-associated proteinFilopodial outgrowthNOS activityGuanylate cyclaseGrowth cone motilityCyclic nucleotide analogsDistinct actionsSynthase substrateCone motilityNOSS-nitrosylationNucleotide analoguesOutgrowth
1996
Nitric oxide-related species inhibit evoked neurotransmission but enhance spontaneous miniature synaptic currents in central neuronal cultures
Pan Z, Segal M, Lipton S. Nitric oxide-related species inhibit evoked neurotransmission but enhance spontaneous miniature synaptic currents in central neuronal cultures. Proceedings Of The National Academy Of Sciences Of The United States Of America 1996, 93: 15423-15428. PMID: 8986827, PMCID: PMC26420, DOI: 10.1073/pnas.93.26.15423.Peer-Reviewed Original ResearchConceptsMiniature excitatory postsynaptic currentsSpontaneous miniature excitatory postsynaptic currentsSpontaneous miniature synaptic currentsExcitatory postsynaptic currentsMiniature synaptic currentsPure NO donorPostsynaptic currentsSynaptic activitySynaptic currentsNeuronal culturesNO donorNitric oxideNO donor moleculesNeurotransmissionNitric oxide-related speciesParadoxical observationEPSCsDonors
1990
VIP-mediated increase in cAMP prevents tetrodotoxin-induced retinal ganglion cell death in vitro
Kaiser P, Lipton S. VIP-mediated increase in cAMP prevents tetrodotoxin-induced retinal ganglion cell death in vitro. Neuron 1990, 5: 373-381. PMID: 2169272, DOI: 10.1016/0896-6273(90)90173-d.Peer-Reviewed Original ResearchConceptsVasoactive intestinal peptideNatural cell deathRGC survivalRetinal ganglion cell deathRetinal ganglion cell neuronsCell deathGanglion cell deathGanglion cell neuronsElectrical blockadePHI-27VIP10-28Intestinal peptideAfferent influencesNeurotrophic effectsNeonatal ratsTetrodotoxin blockadeVIP stimulationRetinal culturesCell neuronsIntact retinaAdenylate cyclaseNormal cell deathElectrical activityDeathRGCs
1985
Conditioning hyperpolarization reveals a property of the light-sensitive current in photoreceptors that is modified by cGMP and EGTA
Lipton S. Conditioning hyperpolarization reveals a property of the light-sensitive current in photoreceptors that is modified by cGMP and EGTA. Brain Research 1985, 341: 337-349. PMID: 2994819, DOI: 10.1016/0006-8993(85)91073-x.Peer-Reviewed Original Research
1983
cGMP and EGTA increase the light-sensitive current of retinal rods
Lipton S. cGMP and EGTA increase the light-sensitive current of retinal rods. Brain Research 1983, 265: 41-48. PMID: 6303507, DOI: 10.1016/0006-8993(83)91331-8.Peer-Reviewed Original Research
1977
Electrical and adaptive properties of rod photoreceptors in Bufo marinus. II. Effects of cyclic nucleotides and prostaglandins.
Lipton S, Rasmussen H, Dowling J. Electrical and adaptive properties of rod photoreceptors in Bufo marinus. II. Effects of cyclic nucleotides and prostaglandins. The Journal Of General Physiology 1977, 70: 771-791. PMID: 201724, PMCID: PMC2228513, DOI: 10.1085/jgp.70.6.771.Peer-Reviewed Original ResearchConceptsCombination of drugsIsolated toad retinaCyclic nucleotide levelsCombination of IBMXResponse amplitudeDrug levelsReceptor sensitivityLong-term exposureReceptor saturationIntracellular cGMPMM IBMXRetinaControl RingerSimilar alterationsElectrical activityCGMPRod photoreceptorsV-log IATPase pumpRod activitySuperfusionDark adaptationOuter segmentsSensitivity recoveryCyclic nucleotides