2023
Aberrant protein S-nitrosylation contributes to hyperexcitability-induced synaptic damage in Alzheimer’s disease: Mechanistic insights and potential therapies
Ghatak S, Nakamura T, Lipton S. Aberrant protein S-nitrosylation contributes to hyperexcitability-induced synaptic damage in Alzheimer’s disease: Mechanistic insights and potential therapies. Frontiers In Neural Circuits 2023, 17: 1099467. PMID: 36817649, PMCID: PMC9932935, DOI: 10.3389/fncir.2023.1099467.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseSynaptic damageReactive oxygen speciesS-nitrosylation contributesNeuronal hyperactivitySynaptic lossSynapse lossSynaptic degenerationCommon causePotential therapyAD modelCognitive declineHyperexcitabilityDiseaseSingle neuronsActivity contributesMolecular changesProtein S-nitrosylationDeleterious effectsNeural network functionS-nitrosylationOxygen speciesEarly signaturesPatientsTherapy
2014
Shallow Encoding and Forgetting Are Associated with Dependence in Instrumental Activities of Daily Living Among Older Adults Living with HIV Infection
Fazeli P, Doyle K, Scott J, Iudicello J, Casaletto K, Weber E, Moore D, Morgan E, Grant I, Woods S, Hampton Atkinson J, Ellis R, Allen McCutchan J, Marcotte T, Marquie-Beck J, Sherman M, Ellis R, Allen McCutchan J, Letendre S, Capparelli E, Schrier R, Rosario D, LeBlanc S, Heaton R, Woods S, Cherner M, Moore D, Morgan E, Dawson M, Jernigan T, Fennema-Notestine C, Archibald S, Hesselink J, Annese J, Taylor M, Masliah E, Achim C, Everall I, Richman D, Smith D, Allen McCutchan J, Achim C, Lipton S, Hampton Atkinson J, Gamst A, Cushman C, Abramson I, Vaida F, Deutsch R, Umlauf A. Shallow Encoding and Forgetting Are Associated with Dependence in Instrumental Activities of Daily Living Among Older Adults Living with HIV Infection. Archives Of Clinical Neuropsychology 2014, 29: 278-288. PMID: 24695591, PMCID: PMC4000232, DOI: 10.1093/arclin/acu009.Peer-Reviewed Original ResearchConceptsCalifornia Verbal Learning Test-Second EditionMemory deficitsIADL dependenceReal-world functioningLogical Memory subtestInstrumental activitiesMemory subtestsShallow encodingRecency effectMemory predictorsDaily livingOlder adultsWorse performanceForgettingOlder groupEncodingOlder HIVADL questionnaireHIV infectionRisk factorsDeficitsHIVAdultsSubtestsYounger cohorts
2001
Potential and Current Use of N-Methyl-D-Aspartate (NMDA) Receptor Antagonists in Diseases of Aging
Le D, Lipton S. Potential and Current Use of N-Methyl-D-Aspartate (NMDA) Receptor Antagonists in Diseases of Aging. Drugs & Aging 2001, 18: 717-724. PMID: 11735619, DOI: 10.2165/00002512-200118100-00001.Peer-Reviewed Original ResearchConceptsReceptor antagonistN-methyl-D-aspartate receptor antagonistN-methyl-D-aspartate (NMDA) receptor complexSafe NMDA antagonistMultiple clinical trialsNMDA receptor antagonistChronic painClinical trialsNMDA antagonistsGlutamate receptorsParkinson's diseaseNeurological disordersNeurodegenerative diseasesDiseaseAdverse effectsAntagonistReceptor complexCurrent useDrugsAdequate levelPainMemantineDysfunctionNitroglycerinStroke
1998
Nitrate therapy may retard glaucomatous optic neuropathy, perhaps through modulation of glutamate receptors
Zurakowski D, Vorwerk C, Gorla M, Kanellopoulos A, Chaturvedi N, Grosskreutz C, Lipton S, Dreyer E. Nitrate therapy may retard glaucomatous optic neuropathy, perhaps through modulation of glutamate receptors. Vision Research 1998, 38: 1489-1494. PMID: 9667013, DOI: 10.1016/s0042-6989(98)00003-0.Peer-Reviewed Original ResearchConceptsEffects of nitroglycerinGlaucomatous optic neuropathyRetinal ganglion cellsAnginal symptomsNitroglycerin preparationsNitrate therapyGlaucomatous damageOptic neuropathyIntraocular pressureGanglion cellsGlutamate receptorsGlaucomatous blindnessNitroglycerinCell deathNeuropathyTherapySymptomsReceptors
1996
Elevated Glutamate Levels in the Vitreous Body of Humans and Monkeys With Glaucoma
Dreyer E, Zurakowski D, Schumer R, Podos S, Lipton S. Elevated Glutamate Levels in the Vitreous Body of Humans and Monkeys With Glaucoma. JAMA Ophthalmology 1996, 114: 299-305. PMID: 8600890, DOI: 10.1001/archopht.1996.01100130295012.Peer-Reviewed Original ResearchConceptsExcitatory amino acid glutamateRetinal ganglion cellsAmino acid glutamateVitreous bodyGlaucomatous eyesGanglion cellsGlutamate levelsRetinal ganglion cell neuronsOptic nerve damageGroup of patientsElevated glutamate levelsGanglion cell neuronsLevels of glutamateEyes of monkeysNerve damageControl eyesVisual dysfunctionNonglaucomatous eyesCataract extractionPosterior capsuleInadvertent ruptureDisease processGlaucomaCell neuronsPatients
1986
Prevention of classic migraine headache by digital massage of the superficial temporal arteries during visual aura
Lipton S. Prevention of classic migraine headache by digital massage of the superficial temporal arteries during visual aura. Annals Of Neurology 1986, 19: 515-516. PMID: 3717913, DOI: 10.1002/ana.410190521.Peer-Reviewed Original Research
1984
Candidal infection in the central nervous system
Lipton S, Hickey W, Morris J, Loscalzo J. Candidal infection in the central nervous system. The American Journal Of Medicine 1984, 76: 101-108. PMID: 6691350, DOI: 10.1016/0002-9343(84)90757-5.Peer-Reviewed Original ResearchConceptsMycotic aneurysmCandidal infectionAntemortem diagnosisAmphotericin BCentral nervous system involvementCentral nervous system candidiasisPercent of patientsCerebrospinal fluid examinationNervous system involvementCentral nervous systemCerebral mycosisInadequate eradicationMeningeal formCerebral involvementParenchymal infectionFluid examinationUnrecognized lesionsDrug therapySystem involvementCerebral vesselsFungus ballRisk factorsDisease entityEarly diagnosisSignificant incidence