1999
Neuroprotection by the NMDA receptor-associated open-channel blocker memantine in a photothrombotic model of cerebral focal ischemia in neonatal rat
Stieg P, Sathi S, Warach S, Le D, Lipton S. Neuroprotection by the NMDA receptor-associated open-channel blocker memantine in a photothrombotic model of cerebral focal ischemia in neonatal rat. European Journal Of Pharmacology 1999, 375: 115-120. PMID: 10443569, DOI: 10.1016/s0014-2999(99)00214-9.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingSide effectsInfarct sizeNeonatal ratsChannel blockersNMDA receptorsFocal cerebral ischemia modelNeurobehavioral side effectsIschemic brain injuryEffects of memantineExcitatory amino acidsInduction of strokeRodent stroke modelsAdult animal modelsCerebral ischemia modelSubstantial side effectsCerebral focal ischemiaNumerous side effectsNeuronal cell culturesNeonatal neuronsPhotochemical thrombosisPhotothrombotic modelNeuronal injuryCerebral ischemiaFocal ischemia
1998
Neuroprotective concentrations of the N-methyl-D-aspartate open-channel blocker memantine are effective without cytoplasmic vacuolation following post-ischemic administration and do not block maze learning or long-term potentiation
Chen H, Wang Y, Rayudu P, Edgecomb P, Neill J, Segal M, Lipton S, Jensen F. Neuroprotective concentrations of the N-methyl-D-aspartate open-channel blocker memantine are effective without cytoplasmic vacuolation following post-ischemic administration and do not block maze learning or long-term potentiation. Neuroscience 1998, 86: 1121-1132. PMID: 9697119, DOI: 10.1016/s0306-4522(98)00163-8.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBody TemperatureBrain IschemiaCytoplasmExcitatory Amino Acid AntagonistsExcitatory Postsynaptic PotentialsIn Vitro TechniquesLong-Term PotentiationMaleMaze LearningMemantineMicroscopy, ElectronNeuronsNeuroprotective AgentsRatsRats, Sprague-DawleyReceptors, N-Methyl-D-AspartateVacuolesConceptsN-methyl-D-aspartate antagonistsLong-term potentiationAspartate antagonistDizocilpine maleateSide effectsUncompetitive N-methyl-D-aspartate antagonistsN-methyl-D-aspartate blockersMorris water maze performancePost-ischemic administrationHypoxia/ischemiaExcitatory postsynaptic currentsN-methyl-D-aspartate (NMDA) channelsAdverse side effectsWater maze performanceHuman CNS disordersExcitotoxic disordersNeuroprotective concentrationsClinical tolerabilityNeuroprotective dosesClinical efficacyInfarct sizePostsynaptic currentsHippocampal slicesCNS disordersAdult ratsTissue plasminogen activator (tPA) increase neuronal damage after focal cerebral ischemia in wild-type and tPA-deficient mice
Wang Y, Tsirka S, Strickland S, Stieg P, Soriano S, Lipton S. Tissue plasminogen activator (tPA) increase neuronal damage after focal cerebral ischemia in wild-type and tPA-deficient mice. Nature Medicine 1998, 4: 228-231. PMID: 9461198, DOI: 10.1038/nm0298-228.Peer-Reviewed Original ResearchConceptsTissue plasminogen activatorTPA-deficient miceWild-type miceCerebral infarctsNeuronal damageEffects of tPAIntravenous tissue plasminogen activatorRole of tPAPlasminogen activatorSmall cerebral infarctsAcute cerebral infarctsFocal cerebral ischemiaMiddle cerebral arteryIschemia/reperfusionStroke-induced injuryCerebral viabilityIntravascular filamentAcute strokeExcitotoxic damageCerebral ischemiaCerebral arteryLarge infarctsIntracerebral injectionIntravenous injectionThrombolytic agents
1991
Calcium Channel Antagonists in the Prevention of Neurotoxicity
Lipton S. Calcium Channel Antagonists in the Prevention of Neurotoxicity. Advances In Pharmacology 1991, 22: 271-297. PMID: 1659865, DOI: 10.1016/s1054-3589(08)60038-1.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrain IschemiaCalciumCalcium Channel BlockersCalcium ChannelsDementiaHumansNeuronsReceptors, N-Methyl-D-AspartateConceptsCalcium channel antagonistsCalcium channelsImportant calcium channelTypes of neurotoxicityPrevention of neurotoxicityPreliminary human studiesNeuroprotective agentsChannel antagonistsPharmacological antagonistsSystemic effectsHuman studiesPrimary neuronsVivo modelAntagonistNeurotoxicityChannel typesNeuronsPrevention