1999
Attenuation of NMDA Receptor Activity and Neurotoxicity by Nitroxyl Anion, NO−
Kim W, Choi Y, Rayudu P, Das P, Asaad W, Arnelle D, Stamler J, Lipton S. Attenuation of NMDA Receptor Activity and Neurotoxicity by Nitroxyl Anion, NO−. Neuron 1999, 24: 461-469. PMID: 10571239, DOI: 10.1016/s0896-6273(00)80859-4.Peer-Reviewed Original ResearchThe contribution of various NOS gene products to HIV-1 coat protein (gp120)-mediated retinal ganglion cell injury.
Dreyer E, Zurakowski D, Gorla M, Vorwerk C, Lipton S. The contribution of various NOS gene products to HIV-1 coat protein (gp120)-mediated retinal ganglion cell injury. Investigative Ophthalmology & Visual Science 1999, 40: 983-9. PMID: 10102296.Peer-Reviewed Original ResearchConceptsNitric oxide synthaseHIV-1 coat proteinRetinal ganglion cell injuryIsoforms of NOSNitric oxideNeuronal nitric oxide synthaseGanglion cell injuryRetinal ganglion cellsPresence of nNOSNOS-deficient miceWild-type miceNeuronal lossExcitotoxic pathwayIntravitreal injectionGanglion cellsGp120 toxicityNeuronal pathologyNOS inhibitorOxide synthaseHIV-1Cell injuryControl animalsNervous systemGp120Pathologic states
1997
Suppression of neuronal apoptosis by S-nitrosylation of caspases
Tenneti L, D'Emilia D, Lipton S. Suppression of neuronal apoptosis by S-nitrosylation of caspases. Neuroscience Letters 1997, 236: 139-142. PMID: 9406756, DOI: 10.1016/s0304-3940(97)00780-5.Peer-Reviewed Original ResearchConceptsS-nitrosylationInterleukin-1beta-converting enzyme-like proteasesCritical cysteine residuesEnzyme-like proteasesApoptotic cell deathHuman embryonic kidneyTranscription factorsEnzyme familyCysteine residuesG proteinsEmbryonic kidneyCell deathCaspasesIon channelsPrimary cerebrocortical neuronsPhysiological activityEnzyme activityActive siteApoptosisNeuronal apoptosisCerebrocortical neuronsFamilyProteinProteaseEnzyme
1995
Regulation of nitric oxide synthase activity in human immunodeficiency virus type 1 (HIV-1)-infected monocytes: implications for HIV-associated neurological disease.
Bukrinsky M, Nottet H, Schmidtmayerova H, Dubrovsky L, Flanagan C, Mullins M, Lipton S, Gendelman H. Regulation of nitric oxide synthase activity in human immunodeficiency virus type 1 (HIV-1)-infected monocytes: implications for HIV-associated neurological disease. Journal Of Experimental Medicine 1995, 181: 735-745. PMID: 7530762, PMCID: PMC2191885, DOI: 10.1084/jem.181.2.735.Peer-Reviewed Original ResearchConceptsEffector cell functionInducible NO synthaseBrain tissueAIDS patientsHIV-1Human immunodeficiency virus (HIV) persistenceHuman immunodeficiency virus type 1Human monocytesNitric oxide synthase activityImmunodeficiency virus type 1HIV-macrophage interactionsPediatric AIDS patientsHIV-1 diseaseCell functionHIV-1 infectionMacrophage antigen presentationExpression of NOSOxide synthase activityVirus-infected macrophagesPostmortem brain tissueVirus type 1Productive viral replicationCultured human monocytesHIV encephalitisHIV replication