2011
Redox modulation by S-nitrosylation contributes to protein misfolding, mitochondrial dynamics, and neuronal synaptic damage in neurodegenerative diseases
Nakamura T, Lipton S. Redox modulation by S-nitrosylation contributes to protein misfolding, mitochondrial dynamics, and neuronal synaptic damage in neurodegenerative diseases. Cell Death & Differentiation 2011, 18: 1478-1486. PMID: 21597461, PMCID: PMC3178424, DOI: 10.1038/cdd.2011.65.Peer-Reviewed Original ResearchConceptsS-nitrosylationProtein misfoldingCritical protein thiolsDynamin-related protein 1Protein disulfide isomeraseS-nitrosylation contributesNitrosative stressPosttranslational modificationsMitochondrial dynamicsNeuronal lossSynaptic damageDownstream pathwaysRedox modulationProtein thiolsNormal neuronal signalingMitochondrial dysfunctionN-methyl-D-aspartate (NMDA) receptor activationNeuronal signalingProtein 1Eventual neuronal lossNeuronal cell damageNeuronal cell injuryMisfoldingNeuronal NO synthaseNeurodegenerative diseases
2006
Activation of the Keap1/Nrf2 pathway for neuroprotection by electrophillic phase II inducers
Satoh T, Okamoto S, Cui J, Watanabe Y, Furuta K, Suzuki M, Tohyama K, Lipton S. Activation of the Keap1/Nrf2 pathway for neuroprotection by electrophillic phase II inducers. Proceedings Of The National Academy Of Sciences Of The United States Of America 2006, 103: 768-773. PMID: 16407140, PMCID: PMC1334635, DOI: 10.1073/pnas.0505723102.Peer-Reviewed Original ResearchConceptsNeurite outgrowth-promoting prostaglandinsHemeoxygenase-1Cerebral ischemia/reperfusion injuryKeap1/Nrf2/HOIschemia/reperfusion injuryGlutamate-related excitotoxicityKeap1/Nrf2 pathwayNrf2/HOHO-1 expressionCultured neuronal cellsInactivation of Nrf2Phase II enzymesThiol-dependent mannerTranscription factor Nrf2HO-1 promoterNeuroprotective actionReperfusion injuryNeuroprotective compoundsNrf2 pathwayTherapeutic approachesNrf2 translocationAntioxidant responsive elementNeurodegenerative disordersNeuronal cellsFactor Nrf2
2005
Nitrosative and oxidative stress links dysfunctional ubiquitination to Parkinson's disease
Gu Z, Nakamura T, Yao D, Shi Z, Lipton S. Nitrosative and oxidative stress links dysfunctional ubiquitination to Parkinson's disease. Cell Death & Differentiation 2005, 12: 1202-1204. PMID: 16094397, DOI: 10.1038/sj.cdd.4401705.Peer-Reviewed Original Research
1997
Neuronal necrosis and apoptosis: two distinct events induced by exposure to glutamate or oxidative stress.
Nicotera P, Ankarcrona M, Bonfoco E, Orrenius S, Lipton S. Neuronal necrosis and apoptosis: two distinct events induced by exposure to glutamate or oxidative stress. Advances In Neurology 1997, 72: 95-101. PMID: 8993688.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisGlutamic AcidHumansMitochondriaNecrosisNeuronsNitric OxideOxidative Stress
1995
Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures.
Bonfoco E, Krainc D, Ankarcrona M, Nicotera P, Lipton S. Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures. Proceedings Of The National Academy Of Sciences Of The United States Of America 1995, 92: 7162-7166. PMID: 7638161, PMCID: PMC41299, DOI: 10.1073/pnas.92.16.7162.Peer-Reviewed Original ResearchConceptsForm of neurotoxicityN-methyl-D-aspartate receptor-mediated neurotoxicityCell damageChronic neurologic disordersNeuronal cell damageCortical cell culturesFinal common pathwayNitric oxide/Superoxide dismutaseS-nitrosocysteineAIDS dementiaNecrotic cell damageFocal ischemiaAcute swellingInitial insultCortical neuronsNeurologic disordersAlzheimer's diseaseNitric oxideNMDANeurodegenerative diseasesHuntington's diseaseIntense exposureNeurotoxicityCommon pathway
1994
Chapter 29 Nitric oxide in the central nervous system
Lipton S, Singel D, Stamler J. Chapter 29 Nitric oxide in the central nervous system. Progress In Brain Research 1994, 103: 359-364. PMID: 7886218, DOI: 10.1016/s0079-6123(08)61149-8.Peer-Reviewed Original ResearchConceptsS-nitrosylationProtein S-nitrosylationNMDA receptorsLevels of thiolsPlasma membraneNitric oxideRedox milieuRelated congenersNMDA receptor activityCentral nervous systemNovel therapeutic strategiesRedox stateFormation of peroxynitriteCell functionAIDS dementiaNeuroprotective pathwaysCerebral ischemiaFocal ischemiaExcessive activationRecent findingsTherapeutic strategiesNervous systemNeurological disordersReceptor activityBiological systemsUpdate on current models of HIV-related neuronal injury: Platelet-activating factor, arachidonic acid and nitric oxide
Lipton S, Yeh M, Dreyer E. Update on current models of HIV-related neuronal injury: Platelet-activating factor, arachidonic acid and nitric oxide. Advances In Neuroimmunology 1994, 4: 181-188. PMID: 7874385, DOI: 10.1016/s0960-5428(06)80255-x.Peer-Reviewed Original ResearchConceptsMacrophages/microgliaNeuronal injuryPlatelet-activating factorArachidonic acidHuman immunodeficiency virus type 1Nitric oxideHIV-1 envelope protein gp120Immunodeficiency virus type 1N-methyl-D-aspartate agonistExistence of HIVBrains of patientsHalf of childrenEnvelope protein gp120Third of adultsVirus type 1Dysfunction of cognitionDemise of neuronsNeurological manifestationsImmunodeficiency syndromeAIDS patientsProtein gp120Neurotoxic substancesHIVMonocytoid cellsExcessive influx