2001
Nitric oxide and respiration
Lipton S. Nitric oxide and respiration. Nature 2001, 413: 119-121. PMID: 11557961, DOI: 10.1038/35093186.Peer-Reviewed Original Research
2000
Redox modulation of the NMDA receptor
Choi Y, Lipton S. Redox modulation of the NMDA receptor. Cellular And Molecular Life Sciences 2000, 57: 1535-1541. PMID: 11092448, PMCID: PMC11147125, DOI: 10.1007/pl00000638.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCysteineNeuronsNitric OxideNitroso CompoundsOxidantsOxidation-ReductionReceptors, N-Methyl-D-AspartateRecombinant ProteinsSulfhydryl CompoundsConceptsRedox modulationCysteine residuesCritical cysteine residuesMultiple cysteine residuesDifferent NMDA receptor subunitsS-nitrosylationMolecular mechanismsMolecular determinantsNMDA receptor subunitsDistinct mechanismsReceptor subunitsPhysiological conditionsSubunitsNR2A subunitImportant mechanismN-methyl-D-aspartate receptorsResiduesNMDA receptorsRedox formsReceptorsCyclic GMPSpeciesMechanismForm of modulationRegulation
1999
Attenuation of NMDA Receptor Activity and Neurotoxicity by Nitroxyl Anion, NO−
Kim W, Choi Y, Rayudu P, Das P, Asaad W, Arnelle D, Stamler J, Lipton S. Attenuation of NMDA Receptor Activity and Neurotoxicity by Nitroxyl Anion, NO−. Neuron 1999, 24: 461-469. PMID: 10571239, DOI: 10.1016/s0896-6273(00)80859-4.Peer-Reviewed Original ResearchRatio of S-nitrosohomocyst(e)ine to homocyst(e)ine or other thiols determines neurotoxicity in rat cerebrocortical cultures
D'Emilia D, Lipton S. Ratio of S-nitrosohomocyst(e)ine to homocyst(e)ine or other thiols determines neurotoxicity in rat cerebrocortical cultures. Neuroscience Letters 1999, 265: 103-106. PMID: 10327179, DOI: 10.1016/s0304-3940(99)00210-4.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DeathCells, CulturedCerebral CortexDose-Response Relationship, DrugHomocysteineNeuronsRatsRats, Sprague-DawleySulfhydryl CompoundsConceptsN-methyl-D-aspartate agonistRat cerebrocortical culturesS-nitrosocysteineS-nitrosohomocysteineNeuronal degenerationCerebrocortical culturesS-nitrosothiolsSubsequent neurotoxicityAcute exposureDetermine outcomeNitric oxideForm peroxynitriteNeurotoxicityS-nitrosylationEndogenous O2S-nitrosoproteinsAgonists
1998
Chapter 6 Redox modulation of the NMDA receptor by NO-related species
Lipton S, Rayudu P, Choi Y, Sucher N, Chen H. Chapter 6 Redox modulation of the NMDA receptor by NO-related species. Progress In Brain Research 1998, 118: 73-82. PMID: 9932435, DOI: 10.1016/s0079-6123(08)63201-x.Peer-Reviewed Original ResearchConceptsChemical reactionsMechanism of reactionRedox stateReactive thiol groupsCatalytic amountFurther oxidationThiol groupsElectron acceptorPreferred reactionReceptor sulfhydryl groupsChemical evidenceSinglet stateNO groupBiological activityMolecular switchReactionThiolsDisulfide bondsSulfhydryl groupsCritical thiolsO2NOS-nitrosylationRedox modulationBonds
1995
Differential modulation by sulfhydryl redox agents and glutathione of GABA- and glycine-evoked currents in rat retinal ganglion cells
Pan Z, Bahring R, Grantyn R, Lipton. Differential modulation by sulfhydryl redox agents and glutathione of GABA- and glycine-evoked currents in rat retinal ganglion cells. Journal Of Neuroscience 1995, 15: 1384-1391. PMID: 7869105, PMCID: PMC6577822, DOI: 10.1523/jneurosci.15-02-01384.1995.Peer-Reviewed Original ResearchConceptsRetinal ganglion cellsRat retinal ganglion cellsGlycine-evoked currentsGanglion cellsInhibitory neurotransmissionSingle retinal ganglion cellsInhibitory neurotransmitter systemsWhole-cell recordingsInhibitory receptor systemsModulatory systemAction of glutathioneNeurotransmitter systemsReceptor stimulationMammalian CNSMammalian retinaSingle agentEndogenous redox agentsReceptor systemPatch pipetteGABADifferential modulationGABAANeurotransmissionRetinaExtracellular glutathione