1991
N-methyl-D-aspartate antagonists prevent kainate neurotoxicity in rat retinal ganglion cells in vitro
Sucher N, Aizenman E, Lipton. N-methyl-D-aspartate antagonists prevent kainate neurotoxicity in rat retinal ganglion cells in vitro. Journal Of Neuroscience 1991, 11: 966-971. PMID: 1672708, PMCID: PMC6575374, DOI: 10.1523/jneurosci.11-04-00966.1991.Peer-Reviewed Original ResearchConceptsRetinal ganglion cellsNMDA receptorsGanglion cellsEndogenous GluKA receptorsSpecific NMDA receptor antagonistN-methyl-D-aspartate antagonistsRetinal ganglion cell deathRat retinal ganglion cellsDoses of NMDAGanglion cell deathSpecific NMDA antagonistNMDA receptor antagonistOwn specific receptorsPatch-clamp electrophysiology experimentsAddition of kainateMicroM kainateKainate neurotoxicityReceptor antagonistNMDA antagonistsKainateCellular injuryExogenous glutamateSpecific receptorsDetectable inhibition
1989
Two pharmacological classes of quisqualate-induced electrical responses in rat retinal ganglion cells in vitro
Aizenman E, Karschin A, Lipton S. Two pharmacological classes of quisqualate-induced electrical responses in rat retinal ganglion cells in vitro. European Journal Of Pharmacology 1989, 174: 9-22. PMID: 2575535, DOI: 10.1016/0014-2999(89)90868-6.Peer-Reviewed Original ResearchConceptsRetinal ganglion cellsRat retinal ganglion cellsGanglion cellsType I cellsPharmacological classesExcitatory amino acid agonistsAmino acid agonistsI cellsType II cellsType III cellsQuisqualate responseCell typesAMPA responsesFurther pharmacological manipulationPharmacological manipulationPharmacological propertiesPatch electrodeII cellsIII cellsAgonistsAntagonistElicited responsesAMPAType IICells