2000
Redox modulation of recombinant human GABAA receptors
Pan Z, Zhang X, Lipton S. Redox modulation of recombinant human GABAA receptors. Neuroscience 2000, 98: 333-338. PMID: 10854765, DOI: 10.1016/s0306-4522(00)00114-7.Peer-Reviewed Original ResearchConceptsGABA receptorsRat retinal ganglion cellsRecombinant human GABAA receptorsRetinal ganglion cellsVoltage-clamp recordingsEffect of dithiothreitolLow GABA concentrationsTwo-electrode voltage-clamp recordingsRedox modulationHuman GABAA receptorsGanglion cellsXenopus oocyte expression systemGABAA receptorsModulatory effectsReceptor currentsOocyte expression systemReceptor responsesGABA concentrationPotentiationGABAReceptorsSubunit compositionHomomeric GABAAgent 5M3 domain
1999
Identification and Mechanism of Action of Two Histidine Residues Underlying High-Affinity Zn2+ Inhibition of the NMDA Receptor
Choi Y, Lipton S. Identification and Mechanism of Action of Two Histidine Residues Underlying High-Affinity Zn2+ Inhibition of the NMDA Receptor. Neuron 1999, 23: 171-180. PMID: 10402203, DOI: 10.1016/s0896-6273(00)80763-1.Peer-Reviewed Original ResearchConceptsNR1/NR2B receptorsNR1/NR2ANR2B receptorsN-methyl-D-aspartate receptor activityMechanism of actionExtracellular N-terminal domainXenopus oocyte expression systemNMDA receptorsVoltage-dependent componentVoltage-dependent blockOocyte expression systemReceptor activityHigh-affinity Zn2Recombinant NR1/NR2ANR2AProton inhibitionReceptorsInhibitionZinc inhibitionCritical determinantHigh affinityNMDANMDAR