1992
Desensitization of GABA-activated currents and channels in cultured cortical neurons
Frosch M, Lipton, Dichter M. Desensitization of GABA-activated currents and channels in cultured cortical neurons. Journal Of Neuroscience 1992, 12: 3042-3053. PMID: 1379634, PMCID: PMC6575652, DOI: 10.1523/jneurosci.12-08-03042.1992.Peer-Reviewed Original ResearchConceptsRate of desensitizationPresence of agonistInhibitory synaptic activationCultured cortical neuronsWhole-cell recording modeApplication of GABAWhole-cell modeDesensitization of GABACortical inhibitionCortical neuronsGABA responsesNeocortical neuronsSynaptic activationSame neuronsGABASingle-channel responsesDesensitizationDesensitization processNeuronsTrue declineAgonistsMembrane conductanceCell culturesRecording modeDose dependence
1991
Cryopreservation of postnatal rat retinal ganglion cells: Persistence of voltage- and ligand-gated ionic currents
Sucher N, Cheng T, Lipton S. Cryopreservation of postnatal rat retinal ganglion cells: Persistence of voltage- and ligand-gated ionic currents. Neuroscience 1991, 43: 135-150. PMID: 1717883, DOI: 10.1016/0306-4522(91)90423-l.Peer-Reviewed Original ResearchConceptsRetinal ganglion cellsGanglion cellsPostnatal rat retinal ganglion cellsOutward currentsRat retinal ganglion cellsCultured retinal ganglion cellsTetraethylammonium-sensitive currentPostnatal retinal ganglion cellsInhibitory amino acidsRetinal cell suspensionsWhole-cell modePatch-clamp techniqueWhole-cell configurationBicuculline methiodideMicroM tetrodotoxinChloride-selective currentsPharmacological sensitivityPotassium currentMicroM Cd2Prolonged time courseAction potentialsProlonged componentsVoltage protocolsSignificant differencesTime course