2006
Mechanism‐Based Development of Memantine as a Therapeutic Agent in Treating Alzheimer's Disease and Other Neurologic Disorders: Low‐Affinity, Uncompetitive Antagonism with Fast Off‐Rate
Chen H, Lipton S. Mechanism‐Based Development of Memantine as a Therapeutic Agent in Treating Alzheimer's Disease and Other Neurologic Disorders: Low‐Affinity, Uncompetitive Antagonism with Fast Off‐Rate. 2006, 439-464. DOI: 10.1002/9780470131862.ch18.Peer-Reviewed Original ResearchTreating Alzheimer's DiseaseNeurologic disordersUncompetitive antagonismAlzheimer's diseaseTherapeutic agentsClinically
1997
Mechanism of memantine block of NMDA‐activated channels in rat retinal ganglion cells: uncompetitive antagonism.
Chen H, Lipton S. Mechanism of memantine block of NMDA‐activated channels in rat retinal ganglion cells: uncompetitive antagonism. The Journal Of Physiology 1997, 499: 27-46. PMID: 9061638, PMCID: PMC1159335, DOI: 10.1113/jphysiol.1997.sp021909.Peer-Reviewed Original ResearchConceptsRat retinal ganglion cellsRetinal ganglion cellsMicroM memantineGanglion cellsUncompetitive antagonismAction of memantineDegree of blockadeConcentrations of NMDARapid superfusion systemWhole-cell recordingsConcentration of agonistDose-response relationshipLow agonist concentrationsNon-competitive actionDose-response curveOpen channel blockerOpen-channel blockadeMemantine actionEndogenous glutamateMicroM NMDAMemantine concentrationsSuperfusion systemMemantine blockMemantineNMDA