Actions of redox-related congeners of nitric oxide at the NMDA receptor
Lipton S, Stamler J. Actions of redox-related congeners of nitric oxide at the NMDA receptor. Neuropharmacology 1994, 33: 1229-1233. PMID: 7870283, DOI: 10.1016/0028-3908(94)90021-3.Peer-Reviewed Original ResearchConceptsProtein S-nitrosylationDisulfide bond formationPlasma membraneS-nitrosylationRedox milieuNovel therapeutic strategiesCell functionMechanistic importanceNMDA receptorsNeuroprotective pathwaysSulfhydryl oxidationNMDA receptor activityBiological systemsPathwayReceptor activityFormation of peroxynitriteHuntington's diseaseReceptorsTherapeutic strategiesCongenersNitric oxideTransductionCa2Excessive activationDownregulation