1994
Actions of redox-related congeners of nitric oxide at the NMDA receptor
Lipton S, Stamler J. Actions of redox-related congeners of nitric oxide at the NMDA receptor. Neuropharmacology 1994, 33: 1229-1233. PMID: 7870283, DOI: 10.1016/0028-3908(94)90021-3.Peer-Reviewed Original ResearchConceptsProtein S-nitrosylationDisulfide bond formationPlasma membraneS-nitrosylationRedox milieuNovel therapeutic strategiesCell functionMechanistic importanceNMDA receptorsNeuroprotective pathwaysSulfhydryl oxidationNMDA receptor activityBiological systemsPathwayReceptor activityFormation of peroxynitriteHuntington's diseaseReceptorsTherapeutic strategiesCongenersNitric oxideTransductionCa2Excessive activationDownregulationChapter 29 Nitric oxide in the central nervous system
Lipton S, Singel D, Stamler J. Chapter 29 Nitric oxide in the central nervous system. Progress In Brain Research 1994, 103: 359-364. PMID: 7886218, DOI: 10.1016/s0079-6123(08)61149-8.Peer-Reviewed Original ResearchConceptsS-nitrosylationProtein S-nitrosylationNMDA receptorsLevels of thiolsPlasma membraneNitric oxideRedox milieuRelated congenersNMDA receptor activityCentral nervous systemNovel therapeutic strategiesRedox stateFormation of peroxynitriteCell functionAIDS dementiaNeuroprotective pathwaysCerebral ischemiaFocal ischemiaExcessive activationRecent findingsTherapeutic strategiesNervous systemNeurological disordersReceptor activityBiological systems
1993
A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds
Lipton S, Choi Y, Pan Z, Lei S, Chen H, Sucher N, Loscalzo J, Singel D, Stamler J. A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds. Nature 1993, 364: 626-632. PMID: 8394509, DOI: 10.1038/364626a0.Peer-Reviewed Original ResearchConceptsNitrogen monoxideRedox-based mechanismComplex redox chemistryS-nitrosylationRedox milieuRedox versatilityRedox chemistryAlternative redox statesNitrosonium ionReceptor thiolsRedox stateNeurotoxic speciesNMDA receptor activityReceptor activationNMDA receptor activationReactionFormation of peroxynitriteThiols