1995
Differential modulation by sulfhydryl redox agents and glutathione of GABA- and glycine-evoked currents in rat retinal ganglion cells
Pan Z, Bahring R, Grantyn R, Lipton. Differential modulation by sulfhydryl redox agents and glutathione of GABA- and glycine-evoked currents in rat retinal ganglion cells. Journal Of Neuroscience 1995, 15: 1384-1391. PMID: 7869105, PMCID: PMC6577822, DOI: 10.1523/jneurosci.15-02-01384.1995.Peer-Reviewed Original ResearchConceptsRetinal ganglion cellsRat retinal ganglion cellsGlycine-evoked currentsGanglion cellsInhibitory neurotransmissionSingle retinal ganglion cellsInhibitory neurotransmitter systemsWhole-cell recordingsInhibitory receptor systemsModulatory systemAction of glutathioneNeurotransmitter systemsReceptor stimulationMammalian CNSMammalian retinaSingle agentEndogenous redox agentsReceptor systemPatch pipetteGABADifferential modulationGABAANeurotransmissionRetinaExtracellular glutathione
1992
Blockade of NMDA receptor-mediated mobilization of intracellular Ca2+ prevents neurotoxicity
Lei S, Zhang D, Abele A, Lipton S. Blockade of NMDA receptor-mediated mobilization of intracellular Ca2+ prevents neurotoxicity. Brain Research 1992, 598: 196-202. PMID: 1486480, DOI: 10.1016/0006-8993(92)90183-a.Peer-Reviewed Original ResearchConceptsIntracellular Ca2Extracellular Ca2Excessive NMDA receptor stimulationRetinal ganglion cell neuronsNMDA receptor-mediated neurotoxicityGanglion cell neuronsNMDA receptor activationReceptor-mediated mobilizationNMDA receptor stimulationNormal extracellular Ca2Neuronal damagePharmacological interventionsPrevents neurotoxicityReceptor stimulationPresence of EGTAIntracellular storesNMDACell neuronsReceptor activationCultured ratDelayed neurotoxicityDantroleneNeurotoxicityElevated Ca2Neurons