Neuronal injury due to HIV-1 envelope protein is blocked by anti-gp120 antibodies but not by anti-CD4 antibodies.
Kaiser P, Offermann J, Lipton S. Neuronal injury due to HIV-1 envelope protein is blocked by anti-gp120 antibodies but not by anti-CD4 antibodies. Neurology 1990, 40: 1757-61. PMID: 2234433, DOI: 10.1212/wnl.40.11.1757.Peer-Reviewed Original ResearchConceptsAnti-CD4 antibodiesNeuronal injuryHuman immunodeficiency virus type 1Retinal ganglion cell neuronsImmunodeficiency virus type 1Absence of superinfectionHIV-1 envelope proteinAnti-gp120 antibodiesGanglion cell neuronsRat T cellsForm of neurotoxicityVirus type 1Envelope proteinNeurologic manifestationsVisual lossImmunodeficiency syndromeCentral neuronsT cellsT lymphocytesHIV-1Protein gp120CD4 moleculeCell neuronsGp120Type 1