2005
Protection against HIV-1 gp120 and HIV-1 Tat neurotoxicity
Kandanearatchi A, Nath A, Lipton S, Masliah, E, Everall I. Protection against HIV-1 gp120 and HIV-1 Tat neurotoxicity. 2005, 201-210. DOI: 10.1093/oso/9780198526100.003.0019.Peer-Reviewed Original ResearchHIV-1 Tat neurotoxicityViral protein gp120HIV-1 gp120HIV infectionInflammatory changesNeuronal damageTat neurotoxicityPoor prognosisProfound dementiaPathogenetic mechanismsNeurocognitive disordersProtein gp120Cognitive impairmentGp120Mechanisms of toxicityCellular damageNeurotoxicityTranscription (STAT) proteinsHIVPrognosisPathogenesisDementiaInfectionImpairmentBrain
1995
The Coat Protein gp120 of HIV‐1 Inhibits Astrocyte Uptake of Excitatory Amino Acids via Macrophage Arachidonic Acid
Dreyer E, Lipton S. The Coat Protein gp120 of HIV‐1 Inhibits Astrocyte Uptake of Excitatory Amino Acids via Macrophage Arachidonic Acid. European Journal Of Neuroscience 1995, 7: 2502-2507. PMID: 8845955, DOI: 10.1111/j.1460-9568.1995.tb01048.x.Peer-Reviewed Original ResearchConceptsExcitatory amino acidsAmino acidsAstrocyte uptakeNeuronal damageProtein gp120Excitatory amino acid uptakeAmino acid uptakeN-methyl-D-aspartate receptorsArachidonic acidCentral mammalian neuronsMammalian neuronsReleases arachidonic acidNeuronal injuryBrain macrophagesImmunodeficiency syndromeNeurological dysfunctionAcid uptakeExcess glutamateGp120MacrophagesAstrocytesNeuronsInitial activationPresent dataUptake
1994
Neuronal Injury Associated with HIV-1 and Potential Treatment with Calcium-Channel and NMDA Antagonists
Lipton S. Neuronal Injury Associated with HIV-1 and Potential Treatment with Calcium-Channel and NMDA Antagonists. Developmental Neuroscience 1994, 16: 145-151. PMID: 7705221, DOI: 10.1159/000112101.Peer-Reviewed Original ResearchConceptsNMDA antagonistsHIV-1HIV-1 envelope protein gp120Existence of HIVBrains of patientsCalcium channel antagonistsVoltage-dependent Ca2Receptor-operated channelsFuture pharmacological interventionsFinal common pathwayAmyotrophic lateral sclerosisEnvelope protein gp120Platelet-activating factorDemise of neuronsInjury AssociatedAIDS dementiaNeuronal injuryGlutamate reuptakeNeurological manifestationsGlutamate releaseImmunodeficiency syndromeChannel antagonistsPharmacological interventionsProtein gp120Lateral sclerosisUpdate on current models of HIV-related neuronal injury: Platelet-activating factor, arachidonic acid and nitric oxide
Lipton S, Yeh M, Dreyer E. Update on current models of HIV-related neuronal injury: Platelet-activating factor, arachidonic acid and nitric oxide. Advances In Neuroimmunology 1994, 4: 181-188. PMID: 7874385, DOI: 10.1016/s0960-5428(06)80255-x.Peer-Reviewed Original ResearchConceptsMacrophages/microgliaNeuronal injuryPlatelet-activating factorArachidonic acidHuman immunodeficiency virus type 1Nitric oxideHIV-1 envelope protein gp120Immunodeficiency virus type 1N-methyl-D-aspartate agonistExistence of HIVBrains of patientsHalf of childrenEnvelope protein gp120Third of adultsVirus type 1Dysfunction of cognitionDemise of neuronsNeurological manifestationsImmunodeficiency syndromeAIDS patientsProtein gp120Neurotoxic substancesHIVMonocytoid cellsExcessive influxCa2+, N-Methyl-d-Aspartate Receptors, and Aids-Related Neuronal Injury
Lipton S. Ca2+, N-Methyl-d-Aspartate Receptors, and Aids-Related Neuronal Injury. International Review Of Neurobiology 1994, 36: 1-27. PMID: 7822116, DOI: 10.1016/s0074-7742(08)60301-3.Peer-Reviewed Original ResearchConceptsN-methyl-D-aspartate (NMDA) receptor-operated channelsN-methyl-D-aspartate receptorsHIV-1 envelope protein gp120Existence of HIVVoltage-dependent Ca2Receptor-operated channelsFuture pharmacological interventionsFinal common pathwayAmyotrophic lateral sclerosisEnvelope protein gp120Demise of neuronsNeuronal injuryAIDS patientsNeuronal susceptibilityPharmacological interventionsProtein gp120Lateral sclerosisParkinson's diseaseMacrophage productionInduces releaseHIVNitric oxideNeurodegenerative diseasesDiseaseHuntington's disease
1992
Requirement for macrophages in neuronal injury induced by HIV envelope protein gp120
Lipton S. Requirement for macrophages in neuronal injury induced by HIV envelope protein gp120. Neuroreport 1992, 3: 913-915. PMID: 1421098, DOI: 10.1097/00001756-199210000-00023.Peer-Reviewed Original ResearchConceptsHIV envelope protein gp120Retinal ganglion cellsEnvelope protein gp120Neuronal injuryGanglion cellsGlial cellsProtein gp120N-methyl-D-aspartate antagonistsMixed neuronal-glial culturesRetinal ganglion cell neuronsNeuronal-glial culturesGanglion cell neuronsActivation of macrophagesPresence of macrophagesPM gp120Like damageGlial culturesCell neuronsGp120Early increaseFree calciumPostnatal retinaMacrophagesInjurious effectsNeuronsMemantine prevents HIV coat protein-induced neuronal injury in vitro.
Lipton S. Memantine prevents HIV coat protein-induced neuronal injury in vitro. Neurology 1992, 42: 1403-5. PMID: 1620355, DOI: 10.1212/wnl.42.7.1403.Peer-Reviewed Original ResearchConceptsNeuronal injuryNeuronal damageHIV-1 coat protein gp120Cognitive/motor complexRat retinal ganglion cellsN-methyl-D-aspartate receptorsHuman immunodeficiency virusPossible protective effectNMDA receptor-operated ion channelsRetinal ganglion cellsReceptor-operated ion channelsMicroM memantineNeurologic deficitsImmunodeficiency virusGanglion cellsNMDA antagonistsProtective effectProtein gp120Therapeutic potentialGp120InjuryMemantineMotor complexConcurrent activationIon channels
1991
Synergistic effects of HIV coat protein and NMDA receptor-mediated neurotoxicity
Lipton S, Sucher N, Kaiser P, Dreyer E. Synergistic effects of HIV coat protein and NMDA receptor-mediated neurotoxicity. Neuron 1991, 7: 111-118. PMID: 1676893, DOI: 10.1016/0896-6273(91)90079-f.Peer-Reviewed Original ResearchConceptsNMDA receptor-mediated neurotoxicityHIV-1 coat protein gp120Whole-cell patch-clamp recordingsHIV coat proteinRat retinal culturesSubsequent neuronal damagePatch-clamp recordingsGlutamate pyruvate transaminaseNeuronal injuryNeuronal damageEndogenous glutamateGanglion cellsNMDA antagonistsProtein gp120Low picomolar concentrationsRetinal culturesGp120NeurotoxicityComplete protectionMinute increasePicomolar concentrationsGlutamateInjuryAntagonistTransaminase
1990
Neuronal injury due to HIV-1 envelope protein is blocked by anti-gp120 antibodies but not by anti-CD4 antibodies.
Kaiser P, Offermann J, Lipton S. Neuronal injury due to HIV-1 envelope protein is blocked by anti-gp120 antibodies but not by anti-CD4 antibodies. Neurology 1990, 40: 1757-61. PMID: 2234433, DOI: 10.1212/wnl.40.11.1757.Peer-Reviewed Original ResearchConceptsAnti-CD4 antibodiesNeuronal injuryHuman immunodeficiency virus type 1Retinal ganglion cell neuronsImmunodeficiency virus type 1Absence of superinfectionHIV-1 envelope proteinAnti-gp120 antibodiesGanglion cell neuronsRat T cellsForm of neurotoxicityVirus type 1Envelope proteinNeurologic manifestationsVisual lossImmunodeficiency syndromeCentral neuronsT cellsT lymphocytesHIV-1Protein gp120CD4 moleculeCell neuronsGp120Type 1HIV-1 Coat Protein Neurotoxicity Prevented by Calcium Channel Antagonists
Dreyer E, Kaiser P, Offermann J, Lipton S. HIV-1 Coat Protein Neurotoxicity Prevented by Calcium Channel Antagonists. Science 1990, 248: 364-367. PMID: 2326646, DOI: 10.1126/science.2326646.Peer-Reviewed Original ResearchConceptsCalcium channel antagonistsHuman immunodeficiency virus type 1Channel antagonistsIntracellular calciumNeuronal injuryDihydropyridine calcium channel antagonist nimodipineCalcium channel antagonist nimodipineImmunodeficiency virus type 1Rodent retinal ganglion cellsGp120-induced increaseChannel antagonist nimodipineRetinal ganglion cellsIntracellular free calciumDose-dependent fashionGp120 envelope proteinVirus type 1Envelope proteinAntagonist nimodipineControl immunoglobulinGanglion cellsHippocampal neuronsProtein gp120Viral envelope proteinsExtracellular calciumNeuronal toxicity