1992
Memantine prevents HIV coat protein-induced neuronal injury in vitro.
Lipton S. Memantine prevents HIV coat protein-induced neuronal injury in vitro. Neurology 1992, 42: 1403-5. PMID: 1620355, DOI: 10.1212/wnl.42.7.1403.Peer-Reviewed Original ResearchConceptsNeuronal injuryNeuronal damageHIV-1 coat protein gp120Cognitive/motor complexRat retinal ganglion cellsN-methyl-D-aspartate receptorsHuman immunodeficiency virusPossible protective effectNMDA receptor-operated ion channelsRetinal ganglion cellsReceptor-operated ion channelsMicroM memantineNeurologic deficitsImmunodeficiency virusGanglion cellsNMDA antagonistsProtective effectProtein gp120Therapeutic potentialGp120InjuryMemantineMotor complexConcurrent activationIon channels
1990
Comparison of delayed administration of competitive and uncompetitive antagonists in preventing NMDA receptor-mediated neuronal death.
Levy D, Lipton S. Comparison of delayed administration of competitive and uncompetitive antagonists in preventing NMDA receptor-mediated neuronal death. Neurology 1990, 40: 852-5. PMID: 1970428, DOI: 10.1212/wnl.40.5.852.Peer-Reviewed Original ResearchConceptsMK-801Uncompetitive antagonistCompetitive antagonistNMDA receptor-mediated neuronal deathN-methyl-D-aspartate receptorsRetinal ganglion cell neuronsStudies of excitotoxicityGanglion cell neuronsGlutamate-induced injuryNeuronal cell deathUncompetitive NMDA antagonistsHypoxia-ischemiaNeurologic injuryProtective dosesNeuronal deathCentral neuronsInitial insultNMDA antagonistsProtective effectCell neuronsAntagonistMinutes of exposureToxic damageInjuryCell death