HIV leucoencephalopathy and TNFα expression in neurones
Rostasy K, Monti L, Lipton S, Hedreen J, Gonzalez R, Navia B. HIV leucoencephalopathy and TNFα expression in neurones. Journal Of Neurology Neurosurgery & Psychiatry 2005, 76: 960. PMID: 15965202, PMCID: PMC1739718, DOI: 10.1136/jnnp.2004.036889.Peer-Reviewed Original ResearchMeSH KeywordsAdultAIDS Dementia ComplexAnti-Retroviral AgentsBasal GangliaBiopsyBrainDiffusion Magnetic Resonance ImagingDisease ProgressionFollow-Up StudiesFrontal LobeHIV Envelope Protein gp41HumansMacrophagesMaleMicrogliaMiddle AgedNeurologic ExaminationNeuronsNeuropsychological TestsSaquinavirStavudineTreatment OutcomeTumor Necrosis Factor-alphaZidovudineConceptsAIDS dementia complexPathogenesis of ADCImaging studiesMicroglia/macrophage activationProgressive formDeep white matter changesMicroglia/macrophagesExpression of TNFalphaWhite matter changesNecrosis factor alphaMeans of immunohistochemistryViral protein expressionNeuroradiological featuresAntiretroviral treatmentHIV infectionThird patientBrain biopsyProgressive dementiaDementia complexTreatment regimensBasal gangliaClinical historyFactor alphaTNFα expressionFrontal cortex