Blockade of electrical activity promotes the death of mammalian retinal ganglion cells in culture.
Lipton S. Blockade of electrical activity promotes the death of mammalian retinal ganglion cells in culture. Proceedings Of The National Academy Of Sciences Of The United States Of America 1986, 83: 9774-9778. PMID: 3025849, PMCID: PMC387224, DOI: 10.1073/pnas.83.24.9774.Peer-Reviewed Original ResearchConceptsRetinal ganglion cellsGanglion cellsNatural cell deathElectrical activityDeath of RGCsMammalian retinal ganglion cellsCell deathLevel of activityPostnatal day 2Spontaneous electrical activityElectrical blockadeIntraocular injectionMicroM tetrodotoxinPostnatal weekNeuronal activitySpontaneous activityTrophic factorsPostnatal ratsMammalian retinaDevelopment neuronsDay 2TetrodotoxinBlockadeIndividual neuronsAltered activity