2000
Evidence for coassembly of mutant GABACρ1 with GABAAγ2S, glycine α1 and glycine α2 receptor subunits in vitro
Pan Z, Zhang D, Zhang X, Lipton S. Evidence for coassembly of mutant GABACρ1 with GABAAγ2S, glycine α1 and glycine α2 receptor subunits in vitro. European Journal Of Neuroscience 2000, 12: 3137-3145. PMID: 10998097, DOI: 10.1046/j.1460-9568.2000.00198.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDose-Response Relationship, DrugElectrophysiologyGABA AntagonistsGamma-Aminobutyric AcidGene ExpressionIn Vitro TechniquesMutagenesisNeural InhibitionOocytesPicrotoxinProtein Structure, TertiaryRatsReceptors, GABAReceptors, GABA-AReceptors, GABA-BReceptors, GlycineRetinaXenopus laevisConceptsGlycine alpha1Rho1 subunitAlpha2 subunitHeteromeric receptorsGABA dose-response curveBlockade of GABAVoltage-clamp recordingsGamma-aminobutyric acidXenopus laevis oocyte expression systemTwo-electrode voltage-clamp recordingsDose-response curveResponse propertiesPicrotoxinin sensitivityOocyte expression systemGamma2 subunitGABAReceptor subunitsPharmacological propertiesReceptorsUnique gatingFunctional evidenceGABAAAlpha1Gamma2Homomeric
1998
Cloning and characterization of mouse GABAC receptor subunits
Greka A, Koolen J, Lipton S, Zhang D. Cloning and characterization of mouse GABAC receptor subunits. Neuroreport 1998, 9: 229-232. PMID: 9507960, DOI: 10.1097/00001756-199801260-00010.Peer-Reviewed Original Research
1992
A slowly inactivating K+ current in retinal ganglion cells from postnatal rat
Sucher N, Lipton S. A slowly inactivating K+ current in retinal ganglion cells from postnatal rat. Visual Neuroscience 1992, 8: 171-176. PMID: 1558829, DOI: 10.1017/s0952523800009330.Peer-Reviewed Original ResearchConceptsRetinal ganglion cellsGanglion cellsPostnatal ratsTiger salamander retinaPatch-clamp techniqueWhole-cell configurationRat neuronsSalamander retinaPharmacological propertiesRatsRelated cellsRetinaVoltage-independent timeCellsExtracellular CO2External applicationChannel typesLower vertebratesLast findingNeuronsTea
1989
Two pharmacological classes of quisqualate-induced electrical responses in rat retinal ganglion cells in vitro
Aizenman E, Karschin A, Lipton S. Two pharmacological classes of quisqualate-induced electrical responses in rat retinal ganglion cells in vitro. European Journal Of Pharmacology 1989, 174: 9-22. PMID: 2575535, DOI: 10.1016/0014-2999(89)90868-6.Peer-Reviewed Original ResearchConceptsRetinal ganglion cellsRat retinal ganglion cellsGanglion cellsType I cellsPharmacological classesExcitatory amino acid agonistsAmino acid agonistsI cellsType II cellsType III cellsQuisqualate responseCell typesAMPA responsesFurther pharmacological manipulationPharmacological manipulationPharmacological propertiesPatch electrodeII cellsIII cellsAgonistsAntagonistElicited responsesAMPAType IICellsSelective modulation of NMDA responses by reduction and oxidation
Aizenman E, Lipton S, Loring R. Selective modulation of NMDA responses by reduction and oxidation. Neuron 1989, 2: 1257-1263. PMID: 2696504, DOI: 10.1016/0896-6273(89)90310-3.Peer-Reviewed Original Research
1988
Responses mediated by excitatory amino acid receptors in solitary retinal ganglion cells from rat.
Aizenman E, Frosch M, Lipton S. Responses mediated by excitatory amino acid receptors in solitary retinal ganglion cells from rat. The Journal Of Physiology 1988, 396: 75-91. PMID: 2842491, PMCID: PMC1192034, DOI: 10.1113/jphysiol.1988.sp016951.Peer-Reviewed Original ResearchConceptsNon-desensitizing currentsDesensitizing componentGanglion cellsInward currentsExcitatory amino acid receptorsExcitatory amino acid responsesAgonist concentrationsWhole-cell voltage-clamp techniqueAmino acid receptorsL-glutamate responsesRetinal ganglion cellsHigh agonist concentrationsAmino acid responsesVoltage-clamp techniqueMicroM kynurenateQuisqualate responseMicroM kainateNMDA responsesNMDA currentsRat retinaAgonist doseQuisqualateAcid receptorsPharmacological propertiesAcid response