2014
Concept of Excitotoxicity via Glutamate Receptors
Piña-Crespo J, Sanz-Blasco S, Lipton S. Concept of Excitotoxicity via Glutamate Receptors. 2014, 1015-1038. DOI: 10.1007/978-1-4614-5836-4_125.Peer-Reviewed Original ResearchDownstream intracellular signaling cascadesIntracellular signaling cascadesGlutamate receptorsPattern of expressionUncovering genesNeuroprotective therapiesIntracellular effectorsSignaling cascadesCell injuryMolecular mechanismsSecond messengerGlutamate receptor overactivationMolecular biologyDisease statesCell deathNeuropsychiatric diseasesNitric oxideInositol phospholipidsAmino acidsCell surfaceConcept of excitotoxicityPotential neuroprotective therapiesExcitatory amino acidsGlutamate-mediated neurotoxicityNerve cell injury
1995
Co-expression of AMPA/kainate receptor-operated channels with high and low Ca2+ permeability in single rat retinal ganglion cells
Zhang D, Sucher N, Lipton S. Co-expression of AMPA/kainate receptor-operated channels with high and low Ca2+ permeability in single rat retinal ganglion cells. Neuroscience 1995, 67: 177-188. PMID: 7477898, DOI: 10.1016/0306-4522(94)00627-h.Peer-Reviewed Original ResearchConceptsRat retinal ganglion cellsRetinal ganglion cellsD-aspartate receptorsReceptor-operated channelsGanglion cellsWhole-cell currentsPermeable AMPA/kainate channelsAMPA/kainate channelsLow Ca2Only permeant cationExtracellular solutionPatch-clamp techniqueSecond groupFirst groupKainate channelsFlop splice variantsPolymerase chain reactionGlutamate receptorsConcentrations of AMPAPattern of expressionReceptorsChain reactionSole charge carrierCurrent-voltage relationshipPredominant expression