2024
A pro-drug derivative of carnosic acid activates the Nrf2 transcriptional pathway and shows efficacy in Alzheimer’s disease transgenic mice
Banerjee P, Roberts A, Natajarian R, Baran P, Lipton S. A pro-drug derivative of carnosic acid activates the Nrf2 transcriptional pathway and shows efficacy in Alzheimer’s disease transgenic mice. Free Radical Biology And Medicine 2024, 224: s96. DOI: 10.1016/j.freeradbiomed.2024.10.212.Peer-Reviewed Original ResearchAlzheimer's disease transgenic miceNrf2 transcriptional pathwayTranscriptional pathwaysCarnosic acidTransgenic mice
2022
Potential Therapeutic Use of the Rosemary Diterpene Carnosic Acid for Alzheimer’s Disease, Parkinson’s Disease, and Long-COVID through NRF2 Activation to Counteract the NLRP3 Inflammasome
Satoh T, Trudler D, Oh C, Lipton S. Potential Therapeutic Use of the Rosemary Diterpene Carnosic Acid for Alzheimer’s Disease, Parkinson’s Disease, and Long-COVID through NRF2 Activation to Counteract the NLRP3 Inflammasome. Antioxidants 2022, 11: 124. PMID: 35052628, PMCID: PMC8772720, DOI: 10.3390/antiox11010124.Peer-Reviewed Original ResearchSARS-CoV-2 infectionParkinson's diseaseAlzheimer's diseaseNeuroprotective effectsNLRP3 inflammasomeKeap1/Nrf2 transcriptional pathwayCarnosic acidAcute lung diseaseBlood-brain barrierChronic neurodegenerative diseasesNLRP3 inflammasome activationCoronavirus disease 2019Nrf2 transcriptional pathwayNLRP3 inflammasome activityPhase 2 enzyme inductionCOVID-19Potential therapeutic useEndovascular cellsBrain fogCytokine stormLong COVIDLung diseaseBrain parenchymaUnregulated inflammationDisease 2019
2009
From Reactive Oxygen and Nitrogen Species to Therapy
McKercher S, Nakamura T, Lipton S. From Reactive Oxygen and Nitrogen Species to Therapy. 2009 DOI: 10.1002/9780470015902.a0021989.Peer-Reviewed Original ResearchReactive oxygen speciesProtein misfoldingS-nitrosylationE3 ubiquitin ligase ParkinUbiquitin ligase ParkinProtein disulfide isomeraseMisfolded protein aggregatesCritical cysteine thiolsS-nitrosylation reactionsExcessive reactive oxygen speciesNrf2 transcriptional pathwayProduction of ROSMisfolded proteinsProtein functionTranscriptional pathwaysCysteine thiolsProtein aggregatesMisfoldingReactive oxygenSpeciesPathological productionOxygen speciesGenetic mutationsNitrogen speciesNeurodegenerative diseases