2006
HIV-1 coreceptors CCR5 and CXCR4 both mediate neuronal cell death but CCR5 paradoxically can also contribute to protection
Kaul M, Ma Q, Medders K, Desai M, Lipton S. HIV-1 coreceptors CCR5 and CXCR4 both mediate neuronal cell death but CCR5 paradoxically can also contribute to protection. Cell Death & Differentiation 2006, 14: 296-305. PMID: 16841089, DOI: 10.1038/sj.cdd.4402006.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virus-1Neuronal cell deathStromal cell-derived factor-1HIV-1 envelope glycoprotein gp120Cell-derived factor-1Cell deathHIV-1 coreceptor CCR5Chemokine receptor CCR5Immunodeficiency virus-1Brain-derived cellsEnvelope glycoprotein gp120Intracellular free Ca2Gp120 neurotoxicityCCR5 ligandsHIV coreceptorsP38 mitogen-activated protein kinaseCCR5 agonistsNeuroprotective pathwaysReceptor CCR5Heterologous desensitizationCoreceptor CCR5CXCR4 agonistCCR5Glial culturesGlycoprotein gp120
2001
Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-κB signalling cascades
Digicaylioglu M, Lipton S. Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-κB signalling cascades. Nature 2001, 412: 641-647. PMID: 11493922, DOI: 10.1038/35088074.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisCell NucleusCells, CulturedDNAErythropoietinGenes, ReporterJanus Kinase 2NeuronsNeuroprotective AgentsNF-kappa BNitric OxideN-MethylaspartateProtein BindingProtein TransportProtein-Tyrosine KinasesProto-Oncogene ProteinsRatsReceptors, ErythropoietinSignal TransductionSuperoxide DismutaseTumor Necrosis Factor-alphaConceptsHypoxia-inducible factor-1EPO receptorForm of JAK2Transcription factor hypoxia-inducible factor-1NF-κB-dependent transcriptionNF-κB functionActivation of JAK2Subsequent nuclear translocationTranscription factor NF-κBNF-κBFactor NF-κBSignaling cascadesNitric oxideKinase 2NF-κB signaling cascadesHypoxic-ischemic preconditioningNuclear translocationNeuroprotective genesFactor 1JAK2Neuroprotective pathwaysNeuronal apoptosisCerebrocortical neuronsEPO effectsDegenerative damage
1994
Actions of redox-related congeners of nitric oxide at the NMDA receptor
Lipton S, Stamler J. Actions of redox-related congeners of nitric oxide at the NMDA receptor. Neuropharmacology 1994, 33: 1229-1233. PMID: 7870283, DOI: 10.1016/0028-3908(94)90021-3.Peer-Reviewed Original ResearchConceptsProtein S-nitrosylationDisulfide bond formationPlasma membraneS-nitrosylationRedox milieuNovel therapeutic strategiesCell functionMechanistic importanceNMDA receptorsNeuroprotective pathwaysSulfhydryl oxidationNMDA receptor activityBiological systemsPathwayReceptor activityFormation of peroxynitriteHuntington's diseaseReceptorsTherapeutic strategiesCongenersNitric oxideTransductionCa2Excessive activationDownregulationChapter 29 Nitric oxide in the central nervous system
Lipton S, Singel D, Stamler J. Chapter 29 Nitric oxide in the central nervous system. Progress In Brain Research 1994, 103: 359-364. PMID: 7886218, DOI: 10.1016/s0079-6123(08)61149-8.Peer-Reviewed Original ResearchConceptsS-nitrosylationProtein S-nitrosylationNMDA receptorsLevels of thiolsPlasma membraneNitric oxideRedox milieuRelated congenersNMDA receptor activityCentral nervous systemNovel therapeutic strategiesRedox stateFormation of peroxynitriteCell functionAIDS dementiaNeuroprotective pathwaysCerebral ischemiaFocal ischemiaExcessive activationRecent findingsTherapeutic strategiesNervous systemNeurological disordersReceptor activityBiological systems