Emerging hiPSC Models for Drug Discovery in Neurodegenerative Diseases
Trudler D, Ghatak S, Lipton S. Emerging hiPSC Models for Drug Discovery in Neurodegenerative Diseases. International Journal Of Molecular Sciences 2021, 22: 8196. PMID: 34360966, PMCID: PMC8347370, DOI: 10.3390/ijms22158196.Peer-Reviewed Original ResearchConceptsAmyotrophic lateral sclerosisNeurodegenerative diseasesParkinson's diseaseAnimal modelsAlzheimer's diseaseEffective disease-modifying therapiesHuntington's diseaseDisease-modifying therapiesSeverity of symptomsHuman samplesHiPSC-derived neural cellsHealthy donorsEffective treatmentLateral sclerosisEconomic burdenHuman-induced pluripotent stem cell (hiPSC) technologyProgressive deteriorationNeural functionDiseaseHiPSC modelsNeural cellsPluripotent stem cell (iPSC) technologyDisease mechanismsPoor accessMillions of people