1999
Identification and Mechanism of Action of Two Histidine Residues Underlying High-Affinity Zn2+ Inhibition of the NMDA Receptor
Choi Y, Lipton S. Identification and Mechanism of Action of Two Histidine Residues Underlying High-Affinity Zn2+ Inhibition of the NMDA Receptor. Neuron 1999, 23: 171-180. PMID: 10402203, DOI: 10.1016/s0896-6273(00)80763-1.Peer-Reviewed Original ResearchConceptsNR1/NR2B receptorsNR1/NR2ANR2B receptorsN-methyl-D-aspartate receptor activityMechanism of actionExtracellular N-terminal domainXenopus oocyte expression systemNMDA receptorsVoltage-dependent componentVoltage-dependent blockOocyte expression systemReceptor activityHigh-affinity Zn2Recombinant NR1/NR2ANR2AProton inhibitionReceptorsInhibitionZinc inhibitionCritical determinantHigh affinityNMDANMDAR
1995
Developmental and regional expression pattern of a novel NMDA receptor- like subunit (NMDAR-L) in the rodent brain
Sucher N, Akbarian S, Chi C, Leclerc C, Awobuluyi M, Deitcher D, Wu M, Yuan J, Jones E, Lipton. Developmental and regional expression pattern of a novel NMDA receptor- like subunit (NMDAR-L) in the rodent brain. Journal Of Neuroscience 1995, 15: 6509-6520. PMID: 7472413, PMCID: PMC6578025, DOI: 10.1523/jneurosci.15-10-06509.1995.Peer-Reviewed Original ResearchConceptsLateral olfactory tractLayer VOlfactory tractEntorhinal cortexRegional expression patternsPostnatal day 1NMDA receptor subunitsFunction of NMDARsGlutamate-activated channelsCA1 fieldInferior colliculiRodent CNSAdult brainLayers IIDay 1Triple combinationRodent brainAxonal outgrowthMRNA expressionReceptor subunitsBrain developmentNMDARSubiculumExpression patternsNeocortex