1992
Models of neuronal injury in AIDS: another role for the NMDA receptor?
Lipton S. Models of neuronal injury in AIDS: another role for the NMDA receptor? Trends In Neurosciences 1992, 15: 75-79. PMID: 1373919, DOI: 10.1016/0166-2236(92)90013-x.Peer-Reviewed Original ResearchConceptsNMDA receptor-operated channelsExistence of HIVVoltage-dependent Ca2Receptor-operated channelsFuture pharmacological interventionsFinal common pathwayDysfunction of cognitionDemise of neuronsNeuronal injuryNeurological manifestationsNeuronal damageImmunodeficiency syndromeAIDS patientsNMDA receptorsNeuronal susceptibilityPharmacological interventionsType 1 resultsCommon pathwayNeuronsPatientsInjuryTwo-thirdsHIVDysfunctionEpilepsy
1991
Calcium channel antagonists attenuate NMDA receptor-mediated neurotoxicity of retinal ganglion cells in culture
Sucher N, Lei S, Lipton S. Calcium channel antagonists attenuate NMDA receptor-mediated neurotoxicity of retinal ganglion cells in culture. Brain Research 1991, 551: 297-302. PMID: 1680525, DOI: 10.1016/0006-8993(91)90944-q.Peer-Reviewed Original ResearchConceptsCalcium channel antagonistsRetinal ganglion cellsChannel antagonistsGanglion cellsPostnatal rat retinal ganglion cellsNMDA receptor-operated channelsRat retinal ganglion cellsNMDA receptor-mediated neurotoxicityVoltage-dependent calcium channelsSelective NMDA antagonistDihydropyridine calcium channel antagonistReceptor-operated channelsVoltage-dependent Ca2Patch-clamp recordingsNMDA antagonistsNMDA receptorsSubsequent toxic effectsCalcium channelsExogenous glutamateRetinal culturesAntagonistL-typeEarly riseInjurious effectsToxic effects