1997
Molecular basis of glutamate toxicity in retinal ganglion cells
Sucher N, Lipton S, Dreyer E. Molecular basis of glutamate toxicity in retinal ganglion cells. Vision Research 1997, 37: 3483-3493. PMID: 9425525, DOI: 10.1016/s0042-6989(97)00047-3.Peer-Reviewed Original ResearchConceptsRetinal ganglion cellsExcitatory amino acidsNMDA receptor antagonistRetinal ischemiaReceptor antagonistGanglion cellsGlutamate toxicityAnterior ischemic optic neuropathyN-methyl-D-aspartate (NMDA) subtypeNMDA receptor-mediated toxicityNon-NMDA receptor subtypesAcute vascular insultCentral artery occlusionOptic nerve traumaIschemic optic neuropathyGlutamate-induced neurotoxicitySelective NMDA receptor antagonistGlutamate-induced depolarizationVoltage-gated Ca2Amino acid glutamateOptic neuritisNerve traumaArtery occlusionFuture clinical useNeuronal loss
1990
Redox modulation of NMDA receptor-mediated toxicity in mammalian central neurons
Levy D, Sucher N, Lipton S. Redox modulation of NMDA receptor-mediated toxicity in mammalian central neurons. Neuroscience Letters 1990, 110: 291-296. PMID: 1970145, DOI: 10.1016/0304-3940(90)90862-4.Peer-Reviewed Original ResearchConceptsCentral neuronsNMDA receptorsN-methyl-D-aspartate (NMDA) subtypeNMDA receptor-mediated toxicityAmyotrophic lateral sclerosis-ParkinsonismAcute neurological injuryGlutamate-induced deathNMDA receptor sitesSurvival of neuronsRetinal ganglion cellsMammalian central neuronsReceptor-operated channelsChronic degenerative diseasesReceptor-mediated toxicityHypoxia-ischemiaNMDA neurotoxicityDementia complexNeurological injurySimilar pathogenesisGanglion cellsGlutamate receptorsEnhanced killingRedox modulationDegenerative diseasesHuntington's disease