1990
VIP-mediated increase in cAMP prevents tetrodotoxin-induced retinal ganglion cell death in vitro
Kaiser P, Lipton S. VIP-mediated increase in cAMP prevents tetrodotoxin-induced retinal ganglion cell death in vitro. Neuron 1990, 5: 373-381. PMID: 2169272, DOI: 10.1016/0896-6273(90)90173-d.Peer-Reviewed Original ResearchConceptsVasoactive intestinal peptideNatural cell deathRGC survivalRetinal ganglion cell deathRetinal ganglion cell neuronsCell deathGanglion cell deathGanglion cell neuronsElectrical blockadePHI-27VIP10-28Intestinal peptideAfferent influencesNeurotrophic effectsNeonatal ratsTetrodotoxin blockadeVIP stimulationRetinal culturesCell neuronsIntact retinaAdenylate cyclaseNormal cell deathElectrical activityDeathRGCs
1988
Spontaneous release of acetylcholine affects the physiological nicotinic responses of rat retinal ganglion cells in culture
Lipton S. Spontaneous release of acetylcholine affects the physiological nicotinic responses of rat retinal ganglion cells in culture. Journal Of Neuroscience 1988, 8: 3857-3868. PMID: 2903915, PMCID: PMC6569610, DOI: 10.1523/jneurosci.08-10-03857.1988.Peer-Reviewed Original ResearchConceptsRetinal ganglion cellsGanglion cellsEndogenous AChRetinal culturesMammalian retinal ganglion cellsOutward currentsRat retinal ganglion cellsCentral mammalian neuronsCholinergic amacrine cellsWhole-cell recordingsConcentrations of AChTonic currentsNicotinic currentsExogenous AChCholinergic responsesNicotinic antagonistsNicotinic responsesAmacrine cellsCentral neuronsNicotinic agonistsD-turbocurarineRetinal cellsTrophic effectsSpontaneous releaseIntact retina