2016
The Veterans Aging Cohort Study (VACS) Index and Neurocognitive Change: A Longitudinal Study
Marquine M, Montoya J, Umlauf A, Fazeli P, Gouaux B, Heaton R, Ellis R, Letendre S, Grant I, Moore D, Group F, Heaton R, Grant I, Atkinson J, Ellis R, Letendre S, Marcotte T, Marquie-Beck J, Sherman M, Ellis R, Letendre S, McCutchan J, Best B, Schrier R, Rosario D, Heaton R, Atkinson J, Woods S, Marcotte T, Cherner M, Moore D, Dawson M, Fennema-Notestine C, Buchsbaum M, Hesselink J, Archibald S, Brown G, Buxton R, Dale A, Liu T, Masliah E, Achim C, Smith D, Richman D, McCutchan J, Cherner M, Achim C, Lipton S, Atkinson J, Marquie-Beck J, Gamst A, Cushman C, Abramson I, Vaida F, Deutsch R, Umlauf A. The Veterans Aging Cohort Study (VACS) Index and Neurocognitive Change: A Longitudinal Study. Clinical Infectious Diseases 2016, 63: 694-702. PMID: 27199461, PMCID: PMC4981756, DOI: 10.1093/cid/ciw328.Peer-Reviewed Original ResearchConceptsVACS Index scoreVeterans Aging Cohort Study (VACS) IndexHigher VACS Index scoresVACS IndexNeurocognitive impairmentIndex scoreT-scoreNeurocognitive changesHIV Neurobehavioral Research ProgramStudy indicesIncident neurocognitive impairmentHuman immunodeficiency virusGlobal deficit scoreSubgroup of personsUpper quartile groupGlobal T-scoresLongitudinal neurocognitive changesCohort studyDeficit scoresImmunodeficiency virusLowest quartileNeurocognitive statusNeurocognitive functionDisease severityComprehensive neurocognitive battery
1992
Memantine prevents HIV coat protein-induced neuronal injury in vitro.
Lipton S. Memantine prevents HIV coat protein-induced neuronal injury in vitro. Neurology 1992, 42: 1403-5. PMID: 1620355, DOI: 10.1212/wnl.42.7.1403.Peer-Reviewed Original ResearchConceptsNeuronal injuryNeuronal damageHIV-1 coat protein gp120Cognitive/motor complexRat retinal ganglion cellsN-methyl-D-aspartate receptorsHuman immunodeficiency virusPossible protective effectNMDA receptor-operated ion channelsRetinal ganglion cellsReceptor-operated ion channelsMicroM memantineNeurologic deficitsImmunodeficiency virusGanglion cellsNMDA antagonistsProtective effectProtein gp120Therapeutic potentialGp120InjuryMemantineMotor complexConcurrent activationIon channels