2014
Concept of Excitotoxicity via Glutamate Receptors
Piña-Crespo J, Sanz-Blasco S, Lipton S. Concept of Excitotoxicity via Glutamate Receptors. 2014, 1015-1038. DOI: 10.1007/978-1-4614-5836-4_125.Peer-Reviewed Original ResearchDownstream intracellular signaling cascadesIntracellular signaling cascadesGlutamate receptorsPattern of expressionUncovering genesNeuroprotective therapiesIntracellular effectorsSignaling cascadesCell injuryMolecular mechanismsSecond messengerGlutamate receptor overactivationMolecular biologyDisease statesCell deathNeuropsychiatric diseasesNitric oxideInositol phospholipidsAmino acidsCell surfaceConcept of excitotoxicityPotential neuroprotective therapiesExcitatory amino acidsGlutamate-mediated neurotoxicityNerve cell injury
2008
Clinically Tolerated Strategies for NMDA Receptor Antagonism
Vincent Chen H, Zhang D, Lipton S. Clinically Tolerated Strategies for NMDA Receptor Antagonism. The Receptors 2008, 327-361. DOI: 10.1007/978-1-59745-055-3_8.Peer-Reviewed Original ResearchExcessive NMDAR activityNMDAR activityClinical trialsGlutamate receptorsSide effectsNeurologic disordersNervous systemAcute hypoxic-ischemic brain injuryGeneralized inhibitionAlzheimer's diseaseSecond-generation memantine derivativesHypoxic-ischemic brain injuryPhase 3 clinical trialsExcessive NMDAR activationSevere neuropathic painExcitatory amino acidsGlutamate-mediated neurotoxicityGlutamate receptor subtypesChronic neurodegenerative diseasesSystemic side effectsMajor excitatory transmitterNormal functionNMDA receptor antagonismGreater neuroprotective propertiesCentral nervous system