2000
Evidence for coassembly of mutant GABACρ1 with GABAAγ2S, glycine α1 and glycine α2 receptor subunits in vitro
Pan Z, Zhang D, Zhang X, Lipton S. Evidence for coassembly of mutant GABACρ1 with GABAAγ2S, glycine α1 and glycine α2 receptor subunits in vitro. European Journal Of Neuroscience 2000, 12: 3137-3145. PMID: 10998097, DOI: 10.1046/j.1460-9568.2000.00198.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDose-Response Relationship, DrugElectrophysiologyGABA AntagonistsGamma-Aminobutyric AcidGene ExpressionIn Vitro TechniquesMutagenesisNeural InhibitionOocytesPicrotoxinProtein Structure, TertiaryRatsReceptors, GABAReceptors, GABA-AReceptors, GABA-BReceptors, GlycineRetinaXenopus laevisConceptsGlycine alpha1Rho1 subunitAlpha2 subunitHeteromeric receptorsGABA dose-response curveBlockade of GABAVoltage-clamp recordingsGamma-aminobutyric acidXenopus laevis oocyte expression systemTwo-electrode voltage-clamp recordingsDose-response curveResponse propertiesPicrotoxinin sensitivityOocyte expression systemGamma2 subunitGABAReceptor subunitsPharmacological propertiesReceptorsUnique gatingFunctional evidenceGABAAAlpha1Gamma2HomomericRedox modulation of recombinant human GABAA receptors
Pan Z, Zhang X, Lipton S. Redox modulation of recombinant human GABAA receptors. Neuroscience 2000, 98: 333-338. PMID: 10854765, DOI: 10.1016/s0306-4522(00)00114-7.Peer-Reviewed Original ResearchConceptsGABA receptorsRat retinal ganglion cellsRecombinant human GABAA receptorsRetinal ganglion cellsVoltage-clamp recordingsEffect of dithiothreitolLow GABA concentrationsTwo-electrode voltage-clamp recordingsRedox modulationHuman GABAA receptorsGanglion cellsXenopus oocyte expression systemGABAA receptorsModulatory effectsReceptor currentsOocyte expression systemReceptor responsesGABA concentrationPotentiationGABAReceptorsSubunit compositionHomomeric GABAAgent 5M3 domain
1995
Multiple GABA receptor subtypes mediate inhibition of calcium influx at rat retinal bipolar cell terminals
Pan Z, Lipton. Multiple GABA receptor subtypes mediate inhibition of calcium influx at rat retinal bipolar cell terminals. Journal Of Neuroscience 1995, 15: 2668-2679. PMID: 7722621, PMCID: PMC6577770, DOI: 10.1523/jneurosci.15-04-02668.1995.Peer-Reviewed Original ResearchConceptsBipolar cell terminalsGABA receptor subtypesGABA receptorsRetinal bipolar cell terminalsGABAC receptorsGABAA receptorsReceptor subtypesCell terminalsMultiple GABA receptorsDihydropyridine-sensitive Ca2Pharmacologic profileCalcium imaging methodSynaptic transmissionCalcium influxSlow onsetInhibitory effectReceptorsSubtypesReversible increaseAgonistsGABACa2FA kineticsFunctional roleInhibitionDifferential modulation by sulfhydryl redox agents and glutathione of GABA- and glycine-evoked currents in rat retinal ganglion cells
Pan Z, Bahring R, Grantyn R, Lipton. Differential modulation by sulfhydryl redox agents and glutathione of GABA- and glycine-evoked currents in rat retinal ganglion cells. Journal Of Neuroscience 1995, 15: 1384-1391. PMID: 7869105, PMCID: PMC6577822, DOI: 10.1523/jneurosci.15-02-01384.1995.Peer-Reviewed Original ResearchConceptsRetinal ganglion cellsRat retinal ganglion cellsGlycine-evoked currentsGanglion cellsInhibitory neurotransmissionSingle retinal ganglion cellsInhibitory neurotransmitter systemsWhole-cell recordingsInhibitory receptor systemsModulatory systemAction of glutathioneNeurotransmitter systemsReceptor stimulationMammalian CNSMammalian retinaSingle agentEndogenous redox agentsReceptor systemPatch pipetteGABADifferential modulationGABAANeurotransmissionRetinaExtracellular glutathione
1992
Desensitization of GABA-activated currents and channels in cultured cortical neurons
Frosch M, Lipton, Dichter M. Desensitization of GABA-activated currents and channels in cultured cortical neurons. Journal Of Neuroscience 1992, 12: 3042-3053. PMID: 1379634, PMCID: PMC6575652, DOI: 10.1523/jneurosci.12-08-03042.1992.Peer-Reviewed Original ResearchConceptsRate of desensitizationPresence of agonistInhibitory synaptic activationCultured cortical neuronsWhole-cell recording modeApplication of GABAWhole-cell modeDesensitization of GABACortical inhibitionCortical neuronsGABA responsesNeocortical neuronsSynaptic activationSame neuronsGABASingle-channel responsesDesensitizationDesensitization processNeuronsTrue declineAgonistsMembrane conductanceCell culturesRecording modeDose dependence
1988
Characterization of GABA- and glycine-induced currents of solitary rodent retinal ganglion cells in culture
Tauck D, Frosch M, Lipton S. Characterization of GABA- and glycine-induced currents of solitary rodent retinal ganglion cells in culture. Neuroscience 1988, 27: 193-203. PMID: 3200439, DOI: 10.1016/0306-4522(88)90230-8.Peer-Reviewed Original ResearchConceptsGanglion cellsBicuculline methiodideRodent retinal ganglion cellsReversal potentialRetinal ganglion cellsWhole-cell recordingsAgonist-induced currentsRodent retinaD-tubocurarineMicroM GABAMicroM glycineReceptor desensitizationGABAPatch electrodeDesensitizationStrychnineMembrane conductancePicrotoxininMethiodideTaurineCellsSolitary cellsSpace clampTissue cultureResponse