2009
Excitotoxicity in Neurodegenerative Disease
Haeberlein S, Lipton S. Excitotoxicity in Neurodegenerative Disease. 2009, 77-86. DOI: 10.1016/b978-008045046-9.00498-8.Peer-Reviewed Original ResearchHuman immunodeficiency virus-associated dementiaExcessive glutamate stimulationSpinal cord traumaMajor excitatory neurotransmitterAmyotrophic lateral sclerosisCord traumaExcitatory neurotransmitterGlutamate stimulationLateral sclerosisParkinson's diseaseTherapeutic interventionsAlzheimer's diseaseNeurodegenerative disordersDiseaseNeurodegenerative diseasesDownstream mechanismsHuntington's diseaseExcitotoxicityBrainSclerosisGlaucomaEpilepsyDementiaStrokeNeurotransmitters
1998
■ REVIEW : Excitotoxicity, Free Radicals, Necrosis, and Apoptosis
Lipton S, Nicotera P. ■ REVIEW : Excitotoxicity, Free Radicals, Necrosis, and Apoptosis. The Neuroscientist 1998, 4: 345-352. DOI: 10.1177/107385849800400516.Peer-Reviewed Original ResearchNitric oxideMajor excitatory neurotransmitterCentral nervous systemFailure of neuronsFree radicalsNeuronal cell culturesActivation of proteasesNeuronal injuryAIDS dementiaNeuronal necrosisInitial insultExcitatory neurotransmitterNervous systemApoptotic death programAlzheimer's diseaseHuntington's diseaseDiseaseInsultExcitotoxicityMitochondrial membrane potentialNecrosisCell deathDeath programNeuronsApoptosis
1996
Neuronal apoptosis versus necrosis induced by glutamate or free radicals
Nicotera P, Ankarcrona M, Bonfoco E, Orrenius S, Lipton S. Neuronal apoptosis versus necrosis induced by glutamate or free radicals. Apoptosis 1996, 1: 5-10. DOI: 10.1007/bf00142073.Peer-Reviewed Original ResearchMajor excitatory neurotransmitterCentral nervous systemFailure of neuronsFree radicalsNeuronal cell culturesNeuronal injuryExcitatory neurotransmitterNeuronal apoptosisNervous systemApoptotic death programNitric oxideInsultInjuryCell deathDeath programNeuronsGlutamateCell culturesApoptosisExcitotoxinsIschemiaEnergy depletionNecrosisNeurotransmittersProgression