2024
Redox regulation, protein S-nitrosylation, and synapse loss in Alzheimer’s and related dementias
Oh C, Nakamura T, Zhang X, Lipton S. Redox regulation, protein S-nitrosylation, and synapse loss in Alzheimer’s and related dementias. Neuron 2024 PMID: 39515322, DOI: 10.1016/j.neuron.2024.10.013.Peer-Reviewed Original ResearchProtein S-nitrosylationS-nitrosylationEndoplasmic reticulumRedox-mediated posttranslational modificationDiseases associated with protein aggregationProtein aggregationSynapse lossModulating protein activityNetwork of proteinsMultiple neurodegenerative disordersUbiquitin-proteasome systemS-nitrosylation reactionPosttranslational modificationsMitochondrial metabolismExcessive nitrosative stressEnzymatic machineryRedox regulationProtein activityProtein networkDysfunction pathwayMicroglial phagocytosisSingle proteinsBioenergetic compromiseReview recent findingsProtein
2001
Assembly with the NR1 Subunit Is Required for Surface Expression of NR3A-Containing NMDA Receptors
Pérez-Otaño I, Schulteis C, Contractor A, Lipton S, Trimmer J, Sucher N, Heinemann S. Assembly with the NR1 Subunit Is Required for Surface Expression of NR3A-Containing NMDA Receptors. Journal Of Neuroscience 2001, 21: 1228-1237. PMID: 11160393, PMCID: PMC6762235, DOI: 10.1523/jneurosci.21-04-01228.2001.Peer-Reviewed Original ResearchConceptsEndoplasmic reticulumNR1-1aPlasma membrane targetingReceptor complexRelative calcium permeabilityNR2 subunitsNR1 subunitSurface expressionMembrane targetingSubunit oligomerizationHeteromultimeric complexesHeteromeric complexesAdditional subunitsNMDA receptor familyPlasma membraneIntracellular traffickingDistinct single-channel propertiesIntracellular clustersFunctional NMDA receptorsSubunitsReceptor familyCell surfaceNMDA receptor subunitsMembrane expressionReticulum