1997
Neurotoxicity associated with dual actions of homocysteine at the N-methyl-d-aspartate receptor
Lipton S, Kim W, Choi Y, Kumar S, D’Emilia D, Rayudu P, Arnelle D, Stamler J. Neurotoxicity associated with dual actions of homocysteine at the N-methyl-d-aspartate receptor. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 5923-5928. PMID: 9159176, PMCID: PMC20882, DOI: 10.1073/pnas.94.11.5923.Peer-Reviewed Original ResearchMeSH Keywords2-Amino-5-phosphonovalerate6-Cyano-7-nitroquinoxaline-2,3-dioneAdultAnimalsCells, CulturedCerebral CortexChildDizocilpine MaleateEmbryo, MammalianEvoked PotentialsGlycineHomocysteineHumansKineticsKynurenic AcidNeuronsNeurotoxinsN-MethylaspartateRatsRats, Sprague-DawleyReceptors, N-Methyl-D-AspartateConceptsN-methyl-D-aspartate receptorsGlycine coagonist siteHomocysteine neurotoxicityNeuronal damageHead traumaVascular diseaseTotal homocysteineNeurotoxic concentrationsGlycine levelsCoagonist siteNeuroprotective activityCoagulation systemNervous systemDisease pathogenesisPartial antagonistExcessive Ca2HomocysteineAdverse effectsElevated levelsPathological conditionsDual actionVessel wallReceptorsReactive oxygen generationPathogenesis
1990
A syndrome of asymmetric limb weakness with motor conduction block.
Krarup C, Stewart J, Sumner A, Pestronk A, Lipton S. A syndrome of asymmetric limb weakness with motor conduction block. Neurology 1990, 40: 118-27. PMID: 2296357, DOI: 10.1212/wnl.40.1.118.Peer-Reviewed Original ResearchConceptsAsymmetric limb weaknessLimb weaknessConduction studiesConduction blockMotor nerve conduction studiesImmune suppressive therapySame nerve segmentAnti-GM1 antibodiesMotor conduction blockNerve conduction studiesSensory conduction studiesSural nerve biopsyAsialo-GM1 antibodyNormal cranial nervesSuppressive therapyNerve biopsyNerve segmentsMotor fibersCranial nervesSensory abnormalitiesPatientsSelective involvementMinimal improvementElevated levelsHigh levels