2007
Neuroinflammation and Excitotoxicity in Neurobiology of HIV-1 Infection and AIDS: Targets for Neuroprotection
Kaul M, Lipton S. Neuroinflammation and Excitotoxicity in Neurobiology of HIV-1 Infection and AIDS: Targets for Neuroprotection. 2007, 281-308. DOI: 10.1007/978-0-387-70830-0_13.Peer-Reviewed Original ResearchHuman immunodeficiency virus-1Central nervous systemMild behavioral abnormalitiesHIV-1 infectionImmune competent cellsImmunodeficiency virus-1Persistent health problemsFrank dementiaImmunodeficiency syndromeMotor dysfunctionInflammatory responseNeurological problemsParticular macrophagesBehavioral abnormalitiesNervous systemHealth problemsVirus 1InfectionBrainCell typesNeuroinflammationExcitotoxicityNeuroprotectionDysfunctionSyndrome
2001
Potential and Current Use of N-Methyl-D-Aspartate (NMDA) Receptor Antagonists in Diseases of Aging
Le D, Lipton S. Potential and Current Use of N-Methyl-D-Aspartate (NMDA) Receptor Antagonists in Diseases of Aging. Drugs & Aging 2001, 18: 717-724. PMID: 11735619, DOI: 10.2165/00002512-200118100-00001.Peer-Reviewed Original ResearchConceptsReceptor antagonistN-methyl-D-aspartate receptor antagonistN-methyl-D-aspartate (NMDA) receptor complexSafe NMDA antagonistMultiple clinical trialsNMDA receptor antagonistChronic painClinical trialsNMDA antagonistsGlutamate receptorsParkinson's diseaseNeurological disordersNeurodegenerative diseasesDiseaseAdverse effectsAntagonistReceptor complexCurrent useDrugsAdequate levelPainMemantineDysfunctionNitroglycerinStroke
1992
Models of neuronal injury in AIDS: another role for the NMDA receptor?
Lipton S. Models of neuronal injury in AIDS: another role for the NMDA receptor? Trends In Neurosciences 1992, 15: 75-79. PMID: 1373919, DOI: 10.1016/0166-2236(92)90013-x.Peer-Reviewed Original ResearchConceptsNMDA receptor-operated channelsExistence of HIVVoltage-dependent Ca2Receptor-operated channelsFuture pharmacological interventionsFinal common pathwayDysfunction of cognitionDemise of neuronsNeuronal injuryNeurological manifestationsNeuronal damageImmunodeficiency syndromeAIDS patientsNMDA receptorsNeuronal susceptibilityPharmacological interventionsType 1 resultsCommon pathwayNeuronsPatientsInjuryTwo-thirdsHIVDysfunctionEpilepsy
1986
Association of Lupuslike Anticoagulant and Nonvasculitic Cerebral Infarction
Tabachnik-Schor N, Lipton S. Association of Lupuslike Anticoagulant and Nonvasculitic Cerebral Infarction. JAMA Neurology 1986, 43: 851-852. PMID: 3089204, DOI: 10.1001/archneur.1986.00520080089033.Peer-Reviewed Original Research