2000
Evidence for coassembly of mutant GABACρ1 with GABAAγ2S, glycine α1 and glycine α2 receptor subunits in vitro
Pan Z, Zhang D, Zhang X, Lipton S. Evidence for coassembly of mutant GABACρ1 with GABAAγ2S, glycine α1 and glycine α2 receptor subunits in vitro. European Journal Of Neuroscience 2000, 12: 3137-3145. PMID: 10998097, DOI: 10.1046/j.1460-9568.2000.00198.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDose-Response Relationship, DrugElectrophysiologyGABA AntagonistsGamma-Aminobutyric AcidGene ExpressionIn Vitro TechniquesMutagenesisNeural InhibitionOocytesPicrotoxinProtein Structure, TertiaryRatsReceptors, GABAReceptors, GABA-AReceptors, GABA-BReceptors, GlycineRetinaXenopus laevisConceptsGlycine alpha1Rho1 subunitAlpha2 subunitHeteromeric receptorsGABA dose-response curveBlockade of GABAVoltage-clamp recordingsGamma-aminobutyric acidXenopus laevis oocyte expression systemTwo-electrode voltage-clamp recordingsDose-response curveResponse propertiesPicrotoxinin sensitivityOocyte expression systemGamma2 subunitGABAReceptor subunitsPharmacological propertiesReceptorsUnique gatingFunctional evidenceGABAAAlpha1Gamma2Homomeric
1997
Mechanism of memantine block of NMDA‐activated channels in rat retinal ganglion cells: uncompetitive antagonism.
Chen H, Lipton S. Mechanism of memantine block of NMDA‐activated channels in rat retinal ganglion cells: uncompetitive antagonism. The Journal Of Physiology 1997, 499: 27-46. PMID: 9061638, PMCID: PMC1159335, DOI: 10.1113/jphysiol.1997.sp021909.Peer-Reviewed Original ResearchConceptsRat retinal ganglion cellsRetinal ganglion cellsMicroM memantineGanglion cellsUncompetitive antagonismAction of memantineDegree of blockadeConcentrations of NMDARapid superfusion systemWhole-cell recordingsConcentration of agonistDose-response relationshipLow agonist concentrationsNon-competitive actionDose-response curveOpen channel blockerOpen-channel blockadeMemantine actionEndogenous glutamateMicroM NMDAMemantine concentrationsSuperfusion systemMemantine blockMemantineNMDA