2000
Neuronal Protection by Nitric Oxide-Related Species
Lipton S, Choi Y, Sucher N, Chen H. Neuronal Protection by Nitric Oxide-Related Species. 2000, 143-152. DOI: 10.1007/978-4-431-67949-3_9.Peer-Reviewed Original ResearchRedox-related speciesFree sulfhydryl groupsSufficient redox potentialNO groupSulfhydryl groupsOrganic synthesisProtein cysteine residuesSingle sulfhydryl groupRedox potentialChemical reactionsRedox agentsCysteine sulfhydrylsDistinctive chemistryAdditional electronLess electronBiological systemsRedox modulationOxideDisulfide bondsCysteine residuesEndogenous redox agentsDifferent biological effectsChemistryElectronsLipoic acid
1999
Neuronal protection and destruction by NO
Lipton S. Neuronal protection and destruction by NO. Cell Death & Differentiation 1999, 6: 943-951. PMID: 10556970, DOI: 10.1038/sj.cdd.4400580.Peer-Reviewed Original ResearchConceptsS-nitrosylationCysteine residuesCaspase enzyme activityNeuronal apoptotic pathwayProtein functionCritical thiol groupsApoptotic pathwayMolecular switchReactive thiol groupsCritical thiolsN-methyl-D-aspartate receptor activityDisulfide bondsRedox stateThiol groupsDeath of neuronsSpeciesDifferent redox statesEnzyme activityDistinct chemical reactivityCaspasesPhysiological conditionsBiological activityActive siteResiduesReceptor activityRedox Sensitivity of NMDA Receptors
Lipton S. Redox Sensitivity of NMDA Receptors. Methods In Molecular Biology 1999, 128: 121-130. PMID: 10320978, DOI: 10.1385/1-59259-683-5:121.Peer-Reviewed Original ResearchConceptsCritical cysteine residuesCysteine residuesRedox modulationProtein cysteine residuesSite-directed mutagenesisEndogenous redox agentsRedox-related speciesFree sulfhydryl groupsProtein functionMolecular dataSulfhydryl groupsSufficient redox potentialCysteine sulfhydrylsRedox sensitivityCell typesNative NMDA receptorsDisulfide bondsNMDA receptor subunitsRedox modulatory siteRecombinant methodsReceptor consistReceptor subunitsOxygen speciesSingle thiol groupResidues
1998
Chapter 6 Redox modulation of the NMDA receptor by NO-related species
Lipton S, Rayudu P, Choi Y, Sucher N, Chen H. Chapter 6 Redox modulation of the NMDA receptor by NO-related species. Progress In Brain Research 1998, 118: 73-82. PMID: 9932435, DOI: 10.1016/s0079-6123(08)63201-x.Peer-Reviewed Original ResearchConceptsChemical reactionsMechanism of reactionRedox stateReactive thiol groupsCatalytic amountFurther oxidationThiol groupsElectron acceptorPreferred reactionReceptor sulfhydryl groupsChemical evidenceSinglet stateNO groupBiological activityMolecular switchReactionThiolsDisulfide bondsSulfhydryl groupsCritical thiolsO2NOS-nitrosylationRedox modulationBondsNO-NMDA Receptor Interactions: A Neuromolecular Approach to Novel Therapeutics
Lipton S, Choi Y, Sucher N, Chen H. NO-NMDA Receptor Interactions: A Neuromolecular Approach to Novel Therapeutics. Ernst Schering Foundation Symposium Proceedings 1998, 95-108. DOI: 10.1007/978-3-662-03596-2_5.Peer-Reviewed Original ResearchRedox-related speciesFree sulfhydryl groupsSufficient redox potentialRedox modulationSulfhydryl groupsProtein cysteine residuesEndogenous redox agentsOrganic synthesisSingle sulfhydryl groupRedox potentialProtein functionRedox agentsCysteine residuesDistinctive chemistryNO groupCell typesDisulfide bondsGroup donorBiological systemsReceptor interactionDifferent biological effectsSpeciesOxygen speciesNovel therapeuticsEndogenous sources