2022
Hidden networks of aberrant protein transnitrosylation contribute to synapse loss in Alzheimer's disease
Lipton S. Hidden networks of aberrant protein transnitrosylation contribute to synapse loss in Alzheimer's disease. Free Radical Biology And Medicine 2022, 193: 171-176. PMID: 36243209, PMCID: PMC9875813, DOI: 10.1016/j.freeradbiomed.2022.10.272.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseParkinson's diseaseNitric oxideSoluble guanylate cyclaseFormation of peroxynitriteSynapse lossNeurocognitive disordersNeurological disordersDiseaseGuanylate cyclaseNeurodevelopmental disordersDisordersProtein S-nitrosylationSuperoxide anionTyrosine nitrationS-nitrosylationHIVS-nitrosationPathogenesisDementia
2021
TCA cycle metabolic compromise due to an aberrant S-nitrosoproteome in HIV-associated neurocognitive disorder with methamphetamine use
Doulias P, Nakamura T, Scott H, McKercher S, Sultan A, Deal A, Albertolle M, Ischiropoulos H, Lipton S. TCA cycle metabolic compromise due to an aberrant S-nitrosoproteome in HIV-associated neurocognitive disorder with methamphetamine use. Journal Of NeuroVirology 2021, 27: 367-378. PMID: 33876414, PMCID: PMC8477648, DOI: 10.1007/s13365-021-00970-4.Peer-Reviewed Original ResearchConceptsNeurocognitive disordersMeth usePathogenesis of HIVHuman postmortem brainAberrant protein S-nitrosylationCNS pathologyControl brainsSynaptic damageS-nitrosylationHIV-1Metabolic compromisePostmortem brainsMethamphetamine useNitric oxideDrug abuseRedox stressNitrosative stressBrainHIVProtein S-nitrosylationDisordersS-nitrosoproteomeSystematic inhibitionTCA cycle enzymesPathogenesis
2016
Health-Related Everyday Functioning in the Internet Age: HIV-Associated Neurocognitive Disorders Disrupt Online Pharmacy and Health Chart Navigation Skills
Woods S, Iudicello J, Morgan E, Cameron M, Doyle K, Smith T, Cushman C, Group T, Grant I, Atkinson J, Ellis R, McCutchan J, Marcotte T, Marquie-Beck J, Sherman M, Ellis R, McCutchan J, Letendre S, Capparelli E, Schrier R, Rosario D, Heaton R, Cherner M, Iudicello J, Moore D, Morgan E, Dawson M, Jernigan T, Fennema-Notestine C, Archibald S, Hesselink J, Annese J, Taylor M, Masliah E, Achim C, Everall I, Richman D, Smith D, McCutchan J, Achim C, Lipton S, Atkinson J, Gamst A, Cushman C, Abramson I, Vaida F, Deutsch R, Umlauf A, DeLuca J, Goverover Y, Franklin D, Corkran S. Health-Related Everyday Functioning in the Internet Age: HIV-Associated Neurocognitive Disorders Disrupt Online Pharmacy and Health Chart Navigation Skills. Archives Of Clinical Neuropsychology 2016, 31: 176-185. PMID: 26743327, PMCID: PMC4758381, DOI: 10.1093/arclin/acv090.Peer-Reviewed Original ResearchConceptsHealth-related behaviorsNeurocognitive disordersHigh plasma viral loadHIV-Associated Neurocognitive DisordersPlasma viral loadEffects of HIVLow health literacyImportant health-related behaviorsHIV infectionViral loadHealth literacyYears of educationOnline pharmaciesStudy participantsPharmacyDisordersFrequent Internet useParticipantsHealthcare managementSeronegativesHIVNavigation skillsInfectionIndividuals