Combating Oxidative/Nitrosative Stress with Electrophilic Counterattack Strategies
Satoh T, Akhtar M, Lipton S. Combating Oxidative/Nitrosative Stress with Electrophilic Counterattack Strategies. 2013, 277-307. DOI: 10.1007/978-94-007-5787-5_10.Peer-Reviewed Original ResearchPro-electrophilic drugsKeap1/Nrf2 pathwayTranscription-dependent pathwayCysteine thiol oxidationNitrosative stressOxidative stressStress-induced oxidationHeat shock proteinsRedox regulationSpecific cysteineProlonged oxidative stressNrf2 pathwayPhase 2 enzymesKeap1/Nrf2Redox stressThiol oxidationElectrophilic compoundsDefense systemHerb rosemaryPathwayNormal cellsCarnosic acidNeurodegenerative disordersCounterattack strategiesDeplete glutathione