ICAM-1 dependent pathway is not involved in the development of neuronal apoptosis after transient focal cerebral ischemia
Soriano S, Wang Y, Lipton S, Dikkes P, Gutierrez-Ramos J, Hickey P. ICAM-1 dependent pathway is not involved in the development of neuronal apoptosis after transient focal cerebral ischemia. Brain Research 1998, 780: 337-341. PMID: 9507184, DOI: 10.1016/s0006-8993(97)01298-5.Peer-Reviewed Original ResearchConceptsFocal cerebral ischemiaCerebral ischemiaTerminal deoxynucleotidyltransferase-mediated dUTP-biotin nick end labeling (TUNEL) stainingICAM-1-dependent pathwayTransient focal cerebral ischemiaICAM-1-deficient miceDUTP-biotin nick end labeling stainingNick end labeling stainingICAM-1 deficiencyNeuronal cell deathEnd labeling stainingPresence of apoptosisIschemic hemisphereNontransgenic littermatesDeficient miceTemporary MCAONeuronal apoptosisBrain sectionsDependent pathwayApoptotic cellsIschemiaNecrosisCell deathMiceApoptosis