1995
Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures.
Bonfoco E, Krainc D, Ankarcrona M, Nicotera P, Lipton S. Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures. Proceedings Of The National Academy Of Sciences Of The United States Of America 1995, 92: 7162-7166. PMID: 7638161, PMCID: PMC41299, DOI: 10.1073/pnas.92.16.7162.Peer-Reviewed Original ResearchConceptsForm of neurotoxicityN-methyl-D-aspartate receptor-mediated neurotoxicityCell damageChronic neurologic disordersNeuronal cell damageCortical cell culturesFinal common pathwayNitric oxide/Superoxide dismutaseS-nitrosocysteineAIDS dementiaNecrotic cell damageFocal ischemiaAcute swellingInitial insultCortical neuronsNeurologic disordersAlzheimer's diseaseNitric oxideNMDANeurodegenerative diseasesHuntington's diseaseIntense exposureNeurotoxicityCommon pathway
1992
Models of neuronal injury in AIDS: another role for the NMDA receptor?
Lipton S. Models of neuronal injury in AIDS: another role for the NMDA receptor? Trends In Neurosciences 1992, 15: 75-79. PMID: 1373919, DOI: 10.1016/0166-2236(92)90013-x.Peer-Reviewed Original ResearchConceptsNMDA receptor-operated channelsExistence of HIVVoltage-dependent Ca2Receptor-operated channelsFuture pharmacological interventionsFinal common pathwayDysfunction of cognitionDemise of neuronsNeuronal injuryNeurological manifestationsNeuronal damageImmunodeficiency syndromeAIDS patientsNMDA receptorsNeuronal susceptibilityPharmacological interventionsType 1 resultsCommon pathwayNeuronsPatientsInjuryTwo-thirdsHIVDysfunctionEpilepsy