2014
Concept of Excitotoxicity via Glutamate Receptors
Piña-Crespo J, Sanz-Blasco S, Lipton S. Concept of Excitotoxicity via Glutamate Receptors. 2014, 1015-1038. DOI: 10.1007/978-1-4614-5836-4_125.Peer-Reviewed Original ResearchDownstream intracellular signaling cascadesIntracellular signaling cascadesGlutamate receptorsPattern of expressionUncovering genesNeuroprotective therapiesIntracellular effectorsSignaling cascadesCell injuryMolecular mechanismsSecond messengerGlutamate receptor overactivationMolecular biologyDisease statesCell deathNeuropsychiatric diseasesNitric oxideInositol phospholipidsAmino acidsCell surfaceConcept of excitotoxicityPotential neuroprotective therapiesExcitatory amino acidsGlutamate-mediated neurotoxicityNerve cell injury
2001
Assembly with the NR1 Subunit Is Required for Surface Expression of NR3A-Containing NMDA Receptors
Pérez-Otaño I, Schulteis C, Contractor A, Lipton S, Trimmer J, Sucher N, Heinemann S. Assembly with the NR1 Subunit Is Required for Surface Expression of NR3A-Containing NMDA Receptors. Journal Of Neuroscience 2001, 21: 1228-1237. PMID: 11160393, PMCID: PMC6762235, DOI: 10.1523/jneurosci.21-04-01228.2001.Peer-Reviewed Original ResearchConceptsEndoplasmic reticulumNR1-1aPlasma membrane targetingReceptor complexRelative calcium permeabilityNR2 subunitsNR1 subunitSurface expressionMembrane targetingSubunit oligomerizationHeteromultimeric complexesHeteromeric complexesAdditional subunitsNMDA receptor familyPlasma membraneIntracellular traffickingDistinct single-channel propertiesIntracellular clustersFunctional NMDA receptorsSubunitsReceptor familyCell surfaceNMDA receptor subunitsMembrane expressionReticulum