2009
Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes
Galluzzi L, Aaronson SA, Abrams J, Alnemri ES, Andrews DW, Baehrecke EH, Bazan NG, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Castedo M, Cidlowski JA, Ciechanover A, Cohen GM, De Laurenzi V, De Maria R, Deshmukh M, Dynlacht BD, El-Deiry WS, Flavell RA, Fulda S, Garrido C, Golstein P, Gougeon ML, Green DR, Gronemeyer H, Hajnóczky G, Hardwick JM, Hengartner MO, Ichijo H, Jäättelä M, Kepp O, Kimchi A, Klionsky DJ, Knight RA, Kornbluth S, Kumar S, Levine B, Lipton SA, Lugli E, Madeo F, Malorni W, Marine J, Martin SJ, Medema JP, Mehlen P, Melino G, Moll UM, Morselli E, Nagata S, Nicholson DW, Nicotera P, Nuñez G, Oren M, Penninger J, Pervaiz S, Peter ME, Piacentini M, Prehn JH, Puthalakath H, Rabinovich GA, Rizzuto R, Rodrigues CM, Rubinsztein DC, Rudel T, Scorrano L, Simon HU, Steller H, Tschopp J, Tsujimoto Y, Vandenabeele P, Vitale I, Vousden KH, Youle RJ, Yuan J, Zhivotovsky B, Kroemer G. Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death & Differentiation 2009, 16: 1093-1107. PMID: 19373242, PMCID: PMC2757140, DOI: 10.1038/cdd.2009.44.Peer-Reviewed Original ResearchConceptsCell deathNumerous human diseasesDead cellsHigher eukaryotesModel organismsCellular demisePhysiological processesHuman diseasesInterpretation of assaysNovel therapeutic strategiesPathological scenariosCell culturesBiomedical researchCellsEukaryotesAssaysTherapeutic strategiesTremendous implicationsOrganismsDeregulationCascadeDozens of methodsDeathDepth investigation
1996
Neuronal apoptosis versus necrosis induced by glutamate or free radicals
Nicotera P, Ankarcrona M, Bonfoco E, Orrenius S, Lipton S. Neuronal apoptosis versus necrosis induced by glutamate or free radicals. Apoptosis 1996, 1: 5-10. DOI: 10.1007/bf00142073.Peer-Reviewed Original ResearchMajor excitatory neurotransmitterCentral nervous systemFailure of neuronsFree radicalsNeuronal cell culturesNeuronal injuryExcitatory neurotransmitterNeuronal apoptosisNervous systemApoptotic death programNitric oxideInsultInjuryCell deathDeath programNeuronsGlutamateCell culturesApoptosisExcitotoxinsIschemiaEnergy depletionNecrosisNeurotransmittersProgression
1992
Desensitization of GABA-activated currents and channels in cultured cortical neurons
Frosch M, Lipton, Dichter M. Desensitization of GABA-activated currents and channels in cultured cortical neurons. Journal Of Neuroscience 1992, 12: 3042-3053. PMID: 1379634, PMCID: PMC6575652, DOI: 10.1523/jneurosci.12-08-03042.1992.Peer-Reviewed Original ResearchConceptsRate of desensitizationPresence of agonistInhibitory synaptic activationCultured cortical neuronsWhole-cell recording modeApplication of GABAWhole-cell modeDesensitization of GABACortical inhibitionCortical neuronsGABA responsesNeocortical neuronsSynaptic activationSame neuronsGABASingle-channel responsesDesensitizationDesensitization processNeuronsTrue declineAgonistsMembrane conductanceCell culturesRecording modeDose dependence