1997
Neuropathogenesis of acquired immunodeficiency syndrome dementia
Lipton S. Neuropathogenesis of acquired immunodeficiency syndrome dementia. Current Opinion In Neurology 1997, 10: 247-253. PMID: 9229134, DOI: 10.1097/00019052-199706000-00014.Peer-Reviewed Original ResearchConceptsImmunodeficiency syndrome (AIDS) dementiaImmunodeficiency syndrome (AIDS) patientsPotential new treatmentCentral nervous systemDevelopment of therapiesAntiretroviral therapyNeuronal injuryBrain macrophagesImmunodeficiency syndromeAntiretroviral drugsNeuronal deathHuman immunodeficiencySurrogate markerClinical trialsSyndrome patientsDirect infectionCerebrospinal fluidNervous systemPast year progressNew treatmentsViral productsTherapyDementiaOne-thirdFurther characterization
1995
The Coat Protein gp120 of HIV‐1 Inhibits Astrocyte Uptake of Excitatory Amino Acids via Macrophage Arachidonic Acid
Dreyer E, Lipton S. The Coat Protein gp120 of HIV‐1 Inhibits Astrocyte Uptake of Excitatory Amino Acids via Macrophage Arachidonic Acid. European Journal Of Neuroscience 1995, 7: 2502-2507. PMID: 8845955, DOI: 10.1111/j.1460-9568.1995.tb01048.x.Peer-Reviewed Original ResearchConceptsExcitatory amino acidsAmino acidsAstrocyte uptakeNeuronal damageProtein gp120Excitatory amino acid uptakeAmino acid uptakeN-methyl-D-aspartate receptorsArachidonic acidCentral mammalian neuronsMammalian neuronsReleases arachidonic acidNeuronal injuryBrain macrophagesImmunodeficiency syndromeNeurological dysfunctionAcid uptakeExcess glutamateGp120MacrophagesAstrocytesNeuronsInitial activationPresent dataUptake
1994
The neuropathogenesis of HIV-1 infection
Gendelman H, Lipton S, Tardieu M, Bukrinsky M, Nottet H. The neuropathogenesis of HIV-1 infection. Journal Of Leukocyte Biology 1994, 56: 389-398. PMID: 8083614, DOI: 10.1002/jlb.56.3.389.Peer-Reviewed Original ResearchConceptsCentral nervous system infectionHIV-1-infected macrophagesBrain tissue pathologyNervous system infectionHIV-1 infectionProductive viral replicationVirus-infected cellsHIV neuropathogenesisMononuclear phagocyte lineageSystem infectionHIV infectionNeuronal damageBrain macrophagesCNS diseaseGlial proliferationGiant cellsTissue pathologyViral replicationSoluble factorsNeurotoxic activityInfectionMacrophagesPhagocyte lineageHIVNeuropathogenesis