Potential Therapeutic Use of the Rosemary Diterpene Carnosic Acid for Alzheimer’s Disease, Parkinson’s Disease, and Long-COVID through NRF2 Activation to Counteract the NLRP3 Inflammasome
Satoh T, Trudler D, Oh C, Lipton S. Potential Therapeutic Use of the Rosemary Diterpene Carnosic Acid for Alzheimer’s Disease, Parkinson’s Disease, and Long-COVID through NRF2 Activation to Counteract the NLRP3 Inflammasome. Antioxidants 2022, 11: 124. PMID: 35052628, PMCID: PMC8772720, DOI: 10.3390/antiox11010124.Peer-Reviewed Original ResearchSARS-CoV-2 infectionParkinson's diseaseAlzheimer's diseaseNeuroprotective effectsNLRP3 inflammasomeKeap1/Nrf2 transcriptional pathwayCarnosic acidAcute lung diseaseBlood-brain barrierChronic neurodegenerative diseasesNLRP3 inflammasome activationCoronavirus disease 2019Nrf2 transcriptional pathwayNLRP3 inflammasome activityPhase 2 enzyme inductionCOVID-19Potential therapeutic useEndovascular cellsBrain fogCytokine stormLong COVIDLung diseaseBrain parenchymaUnregulated inflammationDisease 2019