HIV-1 Coat Protein Neurotoxicity Prevented by Calcium Channel Antagonists
Dreyer E, Kaiser P, Offermann J, Lipton S. HIV-1 Coat Protein Neurotoxicity Prevented by Calcium Channel Antagonists. Science 1990, 248: 364-367. PMID: 2326646, DOI: 10.1126/science.2326646.Peer-Reviewed Original ResearchConceptsCalcium channel antagonistsHuman immunodeficiency virus type 1Channel antagonistsIntracellular calciumNeuronal injuryDihydropyridine calcium channel antagonist nimodipineCalcium channel antagonist nimodipineImmunodeficiency virus type 1Rodent retinal ganglion cellsGp120-induced increaseChannel antagonist nimodipineRetinal ganglion cellsIntracellular free calciumDose-dependent fashionGp120 envelope proteinVirus type 1Envelope proteinAntagonist nimodipineControl immunoglobulinGanglion cellsHippocampal neuronsProtein gp120Viral envelope proteinsExtracellular calciumNeuronal toxicity