Similarity of Neuronal Cell Injury and Death in AIDS Dementia and Focal Cerebral Ischemia: Potential Treatment with NMDA Open‐Channel Blockers and Nitric Oxide‐Related Species
Lipton S. Similarity of Neuronal Cell Injury and Death in AIDS Dementia and Focal Cerebral Ischemia: Potential Treatment with NMDA Open‐Channel Blockers and Nitric Oxide‐Related Species. Brain Pathology 1996, 6: 507-517. PMID: 8944320, DOI: 10.1111/j.1750-3639.1996.tb00879.x.Peer-Reviewed Original ResearchConceptsFocal cerebral ischemiaNeuronal cell deathAIDS dementiaNeuronal injuryCerebral ischemiaNeuronal damageCell injuryHIV-1-associated cognitive/motor complexN-methyl-D-aspartate (NMDA) receptor-operated channelsCognitive/motor complexNMDA open-channel blockersHIV-1 envelope protein gp120Cell deathHIV-1 resultsExistence of HIVNeuronal cell injuryReceptor-operated channelsFuture pharmacological interventionsFinal common pathwayEnvelope protein gp120Platelet-activating factorFree radicalsOpen channel blockerAIDS brainsIschemic core